Observational studyJournal of diabetes investigation2026
Impact of COVID-19 restrictions and their relaxation on body composition and glycemic control in individuals with glucose intolerance in Japan: A single-center observational study.
Observational study in Journal of diabetes investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
AIMS/
introductionDuring the coronavirus disease 2019 (COVID-19) pandemic, Japan imposed voluntary-based restrictions under a state of emergency (SOE) from 2020 to 2021, and nationwide behavioral restrictions ended with its category 5 status in May 2023. The long-term metabolic impact and their behavioral adaptations of these restrictions and relaxation remain unclear in individuals with glucose intolerance (GI). This single-center observational study assessed changes in glycemic control, body composition, and lifestyle changes across the pre-SOE (2019), SOE (2020-2021), and post-SOE (2023) periods in outpatients. MATERIALS AND
methodsWe included 221 outpatients with GI who had complete data for glycated hemoglobin (HbA1c) and body composition in all three periods. Lifestyle changes were evaluated using a questionnaire at post-SOE period.
resultsHbA1c levels gradually increased, with a significant elevation post-SOE compared to pre-SOE. While body weight and BMI remained stable during the SOE, both decreased post-SOE. Fat mass increased during the SOE and thereafter decreased, whereas skeletal muscle mass decreased progressively. Among 68 individuals whose HbA1c worsened during the SOE, 25 experienced further deterioration post-SOE, whereas 43 showed improvements in both glycemic control and body composition. Clustering analysis of questionnaire responses in this subgroup identified two behavioral patterns. One cluster, marked by the combination of persistent reductions in physical activity and increased snacking, showed greater post-SOE HbA1c increases.
conclusionsThis study clarified long-term metabolic effects of COVID-19 restrictions with glycemic deterioration in individuals with GI. In exploratory analysis of those with HbA1c worsening during SOE, behavioral patterns were associated with post-SOE HbA1c changes.
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