Evidence map›Paper›PMID 41954442›Full record

ArticleAmerican journal of physiology. Cell physiology2026

Fluorescence-based quantification of mitochondrial damage in human airway smooth muscle cells.

Sanjana Mahadev Bhat, Gary C Sieck

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Molecular mechanisms underlying FCCP-induced mitophagy in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sanjana Mahadev BhatDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-7597-9597
Gary C SieckDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0003-3040-9424

Funding

Respiratory Control in Old AgeR01AG044615 · NIA · MAYO CLINIC ROCHESTER · PI MANTILLA, CARLOS B, SIECK, GARY C. · 2013 to 2025
$6.9M
Impact of Airway Inflammation on MitochondriaR01HL157984 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2021 to 2024
$2.7M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL157984NHLBI NIH HHS R01 HL157984NIA NIH HHS R01 AG044615
6 · The paper itself

Abstract

Mitochondrial quality control is essential for maintaining cellular homeostasis by balancing the removal of damaged mitochondria (mitophagy) with the generation of new mitochondria (mitochondrial biogenesis). A key feature of mitochondrial damage is loss of mitochondrial membrane potential (ΔΨ

Indexed as

Membrane Potential, MitochondrialMitochondriaMitochondria, MuscleMitophagyMyocytes, Smooth MuscleCarbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCells, CulturedFluorescent DyesGreen Fluorescent ProteinsHumansCarbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneFluorescent DyesGreen Fluorescent Proteinsconfocal imagingdepolarizationmitochondriamitochondrial damagemitochondrial membrane potential

Identifiers

PMID41954442
PMCPMC13112380

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.