Evidence map›Paper›PMID 41954347›Full record

ArticlePathologica2025

Marked hepatic fibrosis with progression towards cirrhosis in generalized arterial calcification of infancy: an unreported association observed in a case carryng a novel

Anna Maria Buccoliero, Giorgia Mancano, Maria Luce Cioni, Caterina Panzuto, Rosangela Artuso, Viviana Palazzo, Giovanni Battista Calabri, Guglielmo Capponi, Abramo Ponticelli, Chiara Caporalini and 5 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Anna Maria BuccolieroPathology Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Giorgia MancanoDivision of Medical Genetics, Meyer Children's Hospital IRCCS, Florence, Italy.
Maria Luce CioniNeonatal Intensive Care Unit, Interdisciplinary Specialistic Department of High-Intensity and Emergency Care , Meyer Children's Hospital IRCCS, Florence, Italy.
Caterina PanzutoNeonatal Intensive Care Unit, Interdisciplinary Specialistic Department of High-Intensity and Emergency Care , Meyer Children's Hospital IRCCS, Florence, Italy.
Rosangela ArtusoDivision of Medical Genetics, Meyer Children's Hospital IRCCS, Florence, Italy.
Viviana PalazzoDivision of Medical Genetics, Meyer Children's Hospital IRCCS, Florence, Italy.
Giovanni Battista CalabriDivision of Medical Genetics, Meyer Children's Hospital IRCCS, Florence, Italy.
Guglielmo CapponiDepartment of Pediatric Cardiology and Congenital Heart Disease, National Research Council-Tuscany Region G. Monasterio Foundation (FTGM), Massa, Pisa, Italy.
Abramo PonticelliPathology Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Chiara CaporaliniPathology Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Federico BertiniDepartment of Radiology, Meyer Children's Hospital IRCCS, Florence, Italy.
Ludovico D'IncertiDepartment of Neuroradiology, Meyer Children's Hospital IRCCS, Florence, Italy.
Elisa SeveriDepartment of Pediatric abdomninal, thoracic and genitourinary surgery, Meyer IRCCS, Florence, Italy.
Angela PeronDepartment of Pediatric abdomninal, thoracic and genitourinary surgery, Meyer IRCCS, Florence, Italy.
Marco MoroniNeonatal Intensive Care Unit, Interdisciplinary Specialistic Department of High-Intensity and Emergency Care , Meyer Children's Hospital IRCCS, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Generalized arterial calcification of infancy (GACI) is a rare autosomal recessive disorder characterized by dysregulated calcium-phosphate metabolism, leading to mineral deposition within the internal elastic lamina of medium- and large-sized arteries. This results in arterial wall thickening and luminal narrowing due to intimal hyperplasia, causing significant vascular disruption. Approximately 70% of cases (GACI type 1) are caused by biallelic loss-of-function mutations in the

Indexed as

Liver CirrhosisPhosphoric Diester HydrolasesPyrophosphatasesVascular CalcificationCodon, NonsenseDisease ProgressionFatal OutcomeHumansInfantCodon, Nonsenseectonucleotide pyrophosphatase phosphodiesterase 1Phosphoric Diester HydrolasesPyrophosphatasesarterial calcificationcirrhosisGACIhepatic fibrosisinfant genetics

Identifiers

PMID41954347
PMCPMC13094313

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.