Evidence map›Paper›PMID 41954292›Full record

ArticleAging cell2026

Single-Cell Profiling Reveals RAB13

Itziar Cenzano, Miguel Cócera, Ana Rosa Lopez-Perez, Lorea Campos-Dopazo, Javier Ruiz, Ignacio Sancho, Patxi San Martin-Uriz, Paula Aguirre-Ruiz, Sarai Sarvide, Amaia Vilas-Zornoza and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Itziar CenzanoHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.ORCID 0000-0002-9030-3069
Miguel CóceraHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
Ana Rosa Lopez-PerezTranslational Bioinformatics Unit, Navarrabiomed, Universidad Pública de Navarra (UPNA), Pamplona, Spain.
Lorea Campos-DopazoHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
Javier RuizHospital Universitario de Navarra, Pamplona, Spain.
Ignacio SanchoInstituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.
Patxi San Martin-UrizHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
Paula Aguirre-RuizHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
Sarai SarvideHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
Amaia Vilas-ZornozaHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
Purificacion Ripalda-CemborainHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
Diego AlignaniHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
Aitziber LopezHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
Marta Miñana BarriosHospital Reina Sofía de Tudela, Navarra, Spain.
Delia Quilez AgredaHospital Reina Sofía de Tudela, Navarra, Spain.
Jin YeBioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Robert LehmannBioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.ORCID 0000-0001-7071-4226
Laura SudupeBioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Marta Abengozar-MuelaDepartament of Pathology, Clinica Universidad de Navarra, Pamplona, Spain.
Álvaro Lopez-JaneiroDepartament of Pathology, Clinica Universidad de Navarra, Pamplona, Spain.
Luis-Esteban Tamariz-AmadorCentro de Investigacion Biomedica en Red de Cancer (CIBERONC). Madrid, Madrid, Spain.
Emma Muiños-LópezHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
Borja SaezHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
Jesper TegnerBioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Isabel A CalvoHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.
David Gomez-CabreroBioscience Program, Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Felipe ProsperHematology and Oncology Program, Centre for Applied Medical Research (CIMA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Navarra, Spain.

Funding

AECC Predoctoral Fellowship PRDNA19006CENZCIBERONC CB16/12/00489Departamento de Industria Gobierno de Navarra AGATA 0011-1411-2020-000010/0011-1411-2020-000011Departamento de Salud Gobierno de NavarraEuropean Commission H2020-MSCA-IF-837491Instituto de Salud Carlos III PI20/01308Instituto de Salud Carlos III PI23/00516Ministerio de Ciencia, Innovación y Universidades FPU22/03283RICORS TERAV and TERAV Plus RD21/0017/0009RICORS TERAV and TERAV Plus RD24/0014/0010Spanish Government PID2019-111192GA-I00
6 · The paper itself

Abstract

The bone marrow (BM) microenvironment plays a crucial role in regulating hematopoiesis, yet the molecular changes associated with aging in humans remain poorly understood. Using single-cell RNA sequencing, we uncovered transcriptional shifts in BM endothelial cells (EC) and mesenchymal stromal cells (MSC) during aging. Aged sinusoidal EC exhibited a prothrombotic phenotype with compromised mitochondrial and vascular function. Additionally, we identified a novel arterial EC subset, emerging in aged individuals, characterized by RAB13 expression and associated with transcriptional regulatory processes. MSC from aged subjects displayed impaired matrix remodeling and epithelial-mesenchymal transition, driven partly by a subpopulation of THY1

Indexed as

AgingBone MarrowBone Marrow CellsEndothelial CellsMesenchymal Stem Cellsrab GTP-Binding ProteinsSingle-Cell AnalysisAdultAgedFemaleHumansMaleSingle-Cell Gene Expression Analysisrab GTP-Binding Proteinsagingendothelial cellshuman bone marrow microenvironmentprofibroticsingle‐cell RNA sequencingstromal cells

Identifiers

PMID41954292
PMCPMC13063395

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.