Evidence map›Paper›PMID 41954268›Full record

ArticleVeterinary medicine and science2026

Isolation, Identification and Pathogenicity Analysis of Proteus mirabilis in Cynomolgus Monkey From Yunnan, China.

Heling Li, Ziyao Qian, Lan Luo, Xinglong Chen, Baohong Tian, Zhigang Chen, Hong Wang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary medicine and science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Heling LiState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
Ziyao QianState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
Lan LuoState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
Xinglong ChenState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
Baohong TianState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
Zhigang ChenState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
Hong WangState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.

Funding

the Natural Science Foundation of Yunnan Province 202102AA100053
6 · The paper itself

Abstract

backgroundProteus mirabilis (P. mirabilis) is an opportunistic zoonotic pathogen that can be mutually transmitted with humans (Homo sapiens); knowledge on P. mirabilis infection in cynomolgus monkeys (Macaca fascicularis) remains limited.

objectivesTo isolate and characterize the diarrhoeal pathogen from a cynomolgus monkey; a bacterial strain MF103012 was isolated from the faeces of a diarrhoeal cynomolgus monkey.

methodsP. mirabilis was identified via morphology, biochemical profiling and 16S rRNA sequencing. Polymerase chain reaction (PCR) was used to detect key virulence genes. Antibiotic susceptibility was determined by Kirby-Bauer disc diffusion using 24 antibiotics of P. mirabilis. Pathogenicity was assessed by intraperitoneal injection in mice.

resultsIn our study, we successfully isolated and identified P. mirabilis from the faeces of diarrhoeal cynomolgus monkey. The isolated strain carried ureC, zapA, rsmA, hpmA, fliL, ucaA and atfA virulence genes. Strain MF103012 was susceptible to 19 antibiotics but resistant to vancomycin and erythromycin, and it induced morbidity and one case of mortality in mice.

conclusionsEndowed with the trait of cross-species transmission, P. mirabilis has become an opportunistic pathogen that requires focused attention in both the prevention and control of zoonoses and clinical anti-infective therapy. The results of this study improve our understanding of the isolated and identified P. mirabilis from the intestinal tract of diarrhoeal cynomolgus monkeys, and also lays groundwork for diagnosis and treatment of P. mirabilis in primate colonies.

Indexed as

DiarrheaMacaca fascicularisMonkey DiseasesProteus InfectionsProteus mirabilisAnimalsAnti-Bacterial AgentsChinaFecesFemaleMaleMiceRNA, Ribosomal, 16SVirulenceAnti-Bacterial AgentsRNA, Ribosomal, 16Sdiarrhoea cynomolgus monkeymolecular identificationpathogenicityvirulence gene

Identifiers

PMID41954268
PMCPMC13063391

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