Evidence map›Paper›PMID 41954190›Full record

Trial reportMolecular nutrition & food research2026

Determination of Folate Bioavailability From Brewer's Yeast in a Dual Isotope Randomized Human Intervention Study.

Nadine Weber, Lisa Striegel, Yvonne Methner, Beate Brandl, Viola Groehn, Jean-Pierre Knapp, Thomas Skurk, Michael Rychlik

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nadine WeberChair of Analytical Food Chemistry, Technical University of Munich, Freising, Germany.
Lisa StriegelChair of Analytical Food Chemistry, Technical University of Munich, Freising, Germany.
Yvonne MethnerResearch Center Weihenstephan for Brewing and Food Quality, Technical University of Munich, Freising, Germany.
Beate BrandlZIEL, Institute for Food & Health, Core Facility Human Studies, Technical University of Munich, Freising, Germany.
Viola GroehnMerck & Cie KmG, Schaffhausen, Switzerland.
Jean-Pierre KnappMerck & Cie KmG, Schaffhausen, Switzerland.
Thomas SkurkZIEL, Institute for Food & Health, Core Facility Human Studies, Technical University of Munich, Freising, Germany.
Michael RychlikChair of Analytical Food Chemistry, Technical University of Munich, Freising, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An adequate intake of folates is primarily dependent on the amount ingested, but also on the bioavailability of these water-soluble vitamins belonging to the vitamin B9 group. Therefore, we here present a human pilot study with a novel dual isotope design to assess the bioavailability of brewer's yeast folate as a model food. The particular advantage of the study design is the use of yeast intrinsically labeled with N-15, and a new reference folate specifically labeled with C-13. In this trial, 6 volunteers consumed (1) the intrinsically

Indexed as

Folic AcidSaccharomyces cerevisiaeAdultBiological AvailabilityCarbon IsotopesFemaleHumansIsotope LabelingMaleNitrogen IsotopesPilot ProjectsTetrahydrofolatesYoung Adult5-methyltetrahydrofolateCarbon IsotopesFolic AcidNitrogen IsotopesTetrahydrofolatesbioavailabilitydual isotope designhuman studyintrinsic labellingstable isotope dilution assayyeast folates

Identifiers

PMID41954190
PMCPMC13063356

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.