ArticleThe Journal of international medical research2026
Half-duration tourniquet plus intra-articular tranexamic acid injection reduces blood loss and improves early recovery after total knee arthroplasty.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BackgroundTotal knee arthroplasty is often complicated by perioperative blood loss. Tourniquets reduce visible bleeding; however, prolonged use may increase hidden blood loss. Intra-articular tranexamic acid may enhance hemostasis without increasing the risk.MethodsWe retrospectively analyzed 85 unilateral primary total knee arthroplasties for osteoarthritis (September 2022 to March 2025). All patients received 1 g intravenous tranexamic acid before incision and were nonrandomly assigned to either of three groups based on evolving institutional protocols and surgeon discretion during the study period as follows: (a) Group A (full-duration tourniquet, n = 28); (b) Group B (half-duration tourniquet, n = 27); and (c) Group C (half-duration tourniquet plus 2 g intra-articular tranexamic acid, n = 30). The primary outcome was postoperative day 3 hemoglobin level; secondary outcomes were calculated blood loss, transfusion, pain scores, early Hospital for Special Surgery knee score (function), and perioperative complications.ResultsA total of eighty-five unilateral primary total knee arthroplasties were analyzed (Group A, n = 28; Group B, n = 27; and Group C, n = 30). Baseline variables were comparable across the three groups. On postoperative day 3, hemoglobin level was highest in Group C (10.97 ± 0.69 g/dL) compared with those in Groups A (9.89 ± 0.80) and B (10.05 ± 0.58) (overall
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