Evidence map›Paper›PMID 41954094›Full record

ArticleAngewandte Chemie (International ed. in English)2026

In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation.

Dongchen Du, László Albert, Milan Weitzel, Linda E Eijsink, Elena R Cotroneo, Dennis Marzin, Felipe Opazo, Nadja A Simeth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dongchen DuInstitute of Organic and Biomolecular Chemistry, University of Goettingen, Goettingen, Germany.
László AlbertInstitute of Neuro- and Sensory Physiology, University Medical Center Goettingen, Goettingen, Germany.
Milan WeitzelInstitute of Organic and Biomolecular Chemistry, University of Goettingen, Goettingen, Germany.
Linda E EijsinkInstitute of Organic and Biomolecular Chemistry, University of Goettingen, Goettingen, Germany.
Elena R CotroneoInstitute of Organic and Biomolecular Chemistry, University of Goettingen, Goettingen, Germany.
Dennis MarzinInstitute of Organic and Biomolecular Chemistry, University of Goettingen, Goettingen, Germany.
Felipe OpazoInstitute of Neuro- and Sensory Physiology, University Medical Center Goettingen, Goettingen, Germany.
Nadja A SimethInstitute of Organic and Biomolecular Chemistry, University of Goettingen, Goettingen, Germany.ORCID 0000-0001-8130-883X

Funding

Deutsche Forschungsgemeinschaft 2067/1-390729940
6 · The paper itself

Abstract

Simple, efficient transformations of fluorogenic nature that proceed under biocompatible conditions without the formation of byproducts are of high interest for in situ labeling and bioconjugation. Following these criteria, we describe in this work the discovery and optimization of imidazopyridinium dyes, obtained through in situ labeling of primary amines with pyridine, quinoline, and isoquinoline aldehydes. The so-generated dyes are excited with near-UV to violet light and emit in the orange region of the electromagnetic spectrum with Stokes shifts up to 12170 cm

Indexed as

Fluorescent DyesImidazolesPyridinium CompoundsAmino AcidsMolecular StructurePeptidesPyridinesQuinolinesAmino AcidsFluorescent DyesImidazolesPeptidespyridinePyridinesPyridinium CompoundsQuinolinesbioimagingfluorogenic labelsin situ labelingpeptide conjugationStokes shift

Identifiers

PMID41954094
PMCPMC13182221

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.