Evidence map›Paper›PMID 41954001›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2026

Aorticorenal Ganglion Ablation Enhances Blood Pressure Reduction After Renal Denervation.

Yuxiang Long, Yinchuan Lai, Yiwen Ren, Xiaomin Ma, Dan Li, Liyuan Chen, Xinyue Liao, Tianli Xia, Zengzhang Liu, Zhiyu Ling and 3 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05590871 (3D Cardiac Electrophysiological Mapping System on Renal Artery Radiofrequency Ablation System for Hypertension), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05590871 narecruitingnot on this map

3D Cardiac Electrophysiological Mapping System on Renal Artery Radiofrequency Ablation System for Hypertension: a Prospective, Multicenter, Randomized Controlled Trial

TypeinterventionalSponsorShanghai Hongdian Medical CO., LTDRan2023 to 2026Enrolled180ConditionsHypertensionArmsFlashPoint renal denervation system, Sham
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuxiang Long *Department of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).ORCID 0000-0003-3150-7616
Yinchuan Lai *Department of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).
Yiwen RenDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).
Xiaomin MaDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).
Dan LiDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).ORCID 0000-0002-5425-5231
Liyuan ChenDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).
Xinyue LiaoDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).
Tianli XiaDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).
Zengzhang LiuDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).ORCID 0000-0001-5225-318X
Zhiyu LingDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).ORCID 0000-0003-1138-9528
Yunlin ChenDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).ORCID 0000-0002-9447-6282
Hao ZhouDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).ORCID 0000-0002-9563-7201
Yuehui YinDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Chongqing Medical University, China (Y. Long, Y. Lai, Y.R., X.M., D.L., L.C., X.L., T.X., Z. Liu, Z. Ling, Y.C., H.Z., Y.Y.).ORCID 0000-0001-9769-435X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aorticorenal ganglion (ARG), an upstream component of renal sympathetic fibers, may represent a novel target for autonomic modulation in hypertension. This study evaluated the effects of adjunctive ARG ablation after renal denervation (RDN) on blood pressure (BP) and its autonomic mechanisms.

methodsPatients with uncontrolled hypertension scheduled for RDN were enrolled, and additional ablation was performed if an elevation in SBP was observed by high-frequency stimulation at the ARG region (RDN+ARG ablation). This exploratory analysis assessed the change in 24-hour average ambulatory systolic BP from baseline to 3 months. To explore the effects of ARG ablation on BP and sympathetic activity, we compared ARG ablation with RDN in a canine model.

resultsA total of 41 patients (n=20 RDN; n=21 RDN+ARG ablation) were enrolled. At 3 months, the reduction in 24-hour average ambulatory systolic BP from baseline was -9.7±10.8 mm Hg in the RDN group and -18.2±10.8 mm Hg in the RDN+ARG ablation group, with a between-group difference of -7.5 mm Hg (95% CI, -13.9 to -1.2 mm Hg;

conclusionsThese results establish the ARG as a pivotal regulator of systemic sympathetic tone and a promising therapeutic target for hypertension. Additional ARG ablation to RDN may represent a more effective interventional strategy, warranting validation in large-scale clinical trials. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05590871.

Indexed as

Blood PressureCatheter AblationGanglia, SympatheticHypertensionKidneySympathectomyAnimalsBlood Pressure Monitoring, AmbulatoryDisease Models, AnimalDogsFemaleHumansMaleTreatment Outcomeblood pressuredogsheart ratenorepinephrinerenal veins

Identifiers

PMID41954001
PMCPMC13275075

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.