Evidence map›Paper›PMID 41953925›Full record

ArticleJournal of pharmaceutical analysis2026

Crebanine protects against ovariectomy-induced bone loss by targeting Sirt1 to interfere with NF-κB acetylation and ROS activity.

Haojie Zhang, Xuan Zhao, Zheng Wang, Jiansen Miao, Xinli Hu, Peng Cui, Chen Jin, Xibin Zhao, Haibo Liang, Hantao Ye and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Haojie ZhangDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Xuan ZhaoDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Zheng WangDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Jiansen MiaoDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Xinli HuDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Peng CuiDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Chen JinDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Xibin ZhaoDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Haibo LiangDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Hantao YeDepartment of Orthopedic Oncology, Ningbo Sixth Hospital, Ningbo, Zhejiang, 315100, China.
Yining XuDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Xiaolong ChenDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Wei WangDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Shibao LuDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis, the most prevalent skeletal disorder, is primarily driven by aberrantly increased osteoclast formation and/or activity. Targeting hyperactive osteoclasts remains the cornerstone of current therapeutic strategies. Crebanine (Cre), a natural isoquinoline-derived alkaloid with diverse pharmacological activities, has not yet been explored for osteoporosis treatment. This study aimed to evaluate the therapeutic potential of Cre against ovariectomy (OVX)-induced osteoporosis and elucidate its underlying mechanisms. Cre dose-dependently inhibited

Indexed as

AcetylationCrebanineOsteoclastOsteoporosisReactive oxygen speciesSirt1

Identifiers

PMID41953925
PMCPMC13054427

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.