ArticleContemporary clinical dentistry
Posttranscriptional Repression of FBXW7 and FBXO8 by microRNA-223 Regulates Ubiquitin-dependent Proteostasis in Periodontal Disease.
Article in Contemporary clinical dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The microRNA-223 (miR-223)/FBXW7/FBXO8 molecular network governs ubiquitin-proteasome proteostasis, a cardinal process in cellular protein turnover. Dysregulation amplifies inflammatory cascades and expedites tissue degradation. This study elucidates stage-specific expression divergences of miRNAs-223 and its cognate F-box regulators in periodontitis. Materials and Methods: This observational study enrolled 100 participants, categorized into five groups comprising periodontally healthy individuals and patients with Stage I-IV Grade B periodontitis. Gingival crevicular fluid (GCF) was collected using calibrated microcapillary pipettes. Total RNA was isolated from the GCF specimens, followed by complementary DNA (cDNA) conversion. Expression levels of miRNAs-223, FBXW7, and FBXO8 across all groups were assessed through the real-time quantitative PCR methodology. Results: Expression analysis of GCF across Groups A (Healthy) to E (Stage IV) revealed statistically significant upregulation of miR-223 (25.38 ± 2.56; Conclusion: The pathophysiological derangement of the miR-223/FBXO8/FBXW7 signaling axis is entwined with aberrant proteolytic dynamics in periodontal pathology, accentuating the indispensable role of F-box-dependent ubiquitin-mediated degradation and positioning this molecular ensemble as a promising conduit for therapeutic stratagem.
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