Evidence map›Paper›PMID 41953680›Full record

ArticleFrontiers in cellular and infection microbiology2026

Emergence of multidrug-resistant ST876 serotype 14

Lin Liu, Shouyuan Chen, Tingting Hong, Ying Fu, Yining Ye, Yuxiaoting Li, Tingting Li, Tailong Lei, Yan Chen, Yanfei Wang and 3 more

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Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lin Liu *Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Shouyuan Chen *Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Tingting Hong *Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Ying FuDepartment of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Yining YeDepartment of Infectious Disease, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yuxiaoting LiDepartment of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Tingting LiDepartment of Clinical Laboratory, the First People's Hospital of Linhai, Linhai, Zhejiang, China.
Tailong LeiDepartment of Infectious Disease, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yan ChenDepartment of Clinical Laboratory, Jiangshan People's Hospital, Quzhou, Zhejiang, China.
Yanfei WangDepartment of Infectious Disease, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Dongdong ZhaoDepartment of Infectious Disease, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xueqing Wu *Department of Infectious Disease, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yunsong Yu *Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: Two ST876 serotype 14 strains, hz23B (blood) and hz23P (pericardial effusion), were isolated from one purulent pericarditis patient. We determined antimicrobial susceptibility test (AST) by broth microdilution, performed whole-genome sequencing and mutation detection, multi-locus sequencing typing, and phylogenetic analysis against 1429 global serotype 14 genomes, modeled protein structures for unique mutations, and quantified growth under anaerobic/low-nutrient conditions, plus adherence and invasion on nasopharyngeal and lung epithelial cell lines. Results: Both isolates showed an identical AST profile, where a multidrug-resistant phenotype was observed. Genomes differed by only 36 SNPs, while hz23P acquired CiaH_W192L (transmembrane kinase loss) and FabT_E21A (DNA-binding reduction). These changes conferred hz23P's enhanced growth in THY and BSA+G under anaerobic stress ( Conclusions: We provide the first real-time evidence that ST876 serotype 14 pneumococci evolve within the host to survive the pericardial environment by attenuating virulence and energy. The global screen underscores the urgent need for surveillance targeting this multidrug-resistant and virulent clone.

Indexed as

Drug Resistance, Multiple, BacterialMutationPericarditisPneumococcal InfectionsStreptococcus pneumoniaeAnti-Bacterial AgentsBacterial AdhesionCell LineEpithelial CellsGenome, BacterialHumansMicrobial Sensitivity TestsPhylogenySerogroupVirulenceWhole Genome SequencingAnti-Bacterial AgentsCiaHFabTheart infectionpericarditispneumococcusserotype 14ST876

Identifiers

PMID41953680
PMCPMC13053516

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.