ArticleRSC advances2026
Motif-designed peptide nanofibers as bioactive surface modifiers for biomimetic hydroxyapatite formation on demineralized porous dentin.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dentin hypersensitivity (DH) is closely associated with mineral loss and subsequent exposure of dentinal tubules, which underscores the need for biomimetic strategies capable of restoring dentin as an organic-inorganic composite. In this work, a short peptide (KLVFFAKMLPHHGA) was designed by integrating a self-assembly motif with a mineralization-inducing segment, aiming to promote dentin remineralization. The peptide readily formed stable nanofibrous assemblies in ethanol containing 0.1% (v/v) trifluoroacetic acid (TFA; TFA : ethanol = 1 : 9) at 37 °C. These peptide nanofibers (PNFs) could be immobilized onto the demineralized dentin surface and acted as organic frameworks for calcium phosphate deposition. After
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