ArticleJournal of clinical medicine research2026
The MAGENTA Model for Individual Prediction of In-Hospital Mortality in Chronic Obstructive Pulmonary Disease With Acute Exacerbation: An External Validation Study.
Article in Journal of clinical medicine research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The MAGENTA score identifies acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients at high risk of in-hospital mortality to guide monitoring and treatment, yet its generalizability requires confirmation. This study aimed to externally validate the performance of the MAGENTA model. Methods: We conducted a temporal external validation using retrospective data from 938 admission records of patients hospitalized in general wards and intensive care units at a tertiary center in Thailand (2018-2019). The model, which utilizes mean arterial pressure, age, blood urea nitrogen, endotracheal intubation, sodium, temperature, and albumin, was evaluated regarding all-cause in-hospital mortality. Results: The validation cohort had an 11.2% mortality rate with moderate case-mix differences compared to the development set. The model demonstrated acceptable discrimination with an area under the curve (AUC) of 0.75 (95% confidence interval (CI), 0.70-0.80), though lower than the AUC in the original derivation. Calibration analysis revealed systematic overprediction (expected-to-observed (E:O) ratio of 1.335) and overfitting (slope of 0.536), particularly when the predicted risk exceeded 20%. Importantly, recalibration of the intercept and slope substantially improved the agreement between predicted and observed risks. Conclusions: While the MAGENTA model offers acceptable discriminative ability for stratifying AECOPD mortality risk, local recalibration is recommended to address overestimation in high-risk patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.