ArticleJournal of pharmacopuncture2026
Safety Evaluation of Spray-Dried
Article in Journal of pharmacopuncture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
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Abstract
Objectives: Methods: Spray-dried CLE (SDCLE) was prepared by spray-drying CLE with lactose (19 w/w) as the microencapsulation agent. The curcuminoid composition was quantified using a validated high-performance thin-layer chromatography (HP-TLC) method. The solubility of SDCLE was compared with that of native CLE (NCLE). Acute toxicity (LC Results: SDCLE, formulated to contain 10% (w/w) NCLE, exhibited a curcumin content of 0.148 ± 0.02 mg/g. This formulation showed markedly enhanced aqueous solubility (91.30% at a 130 dilution) compared with NCLE alone (55.78% at the same dilution), yielding clear, homogeneous solutions suitable for parenteral administration. Post-exposure acute toxicity assessment in zebrafish revealed a time-dependent decrease in LC Conclusion: Spray-drying overcame the solubility limitations of CLE, enabling aqueous reconstitution for pharmacopuncture applications. A 96-hour LC
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