ArticleFrontiers in nutrition2026
Association of lipid parameters with the development of disease complications in patients with limited cutaneous systemic sclerosis: a prospective exploratory cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Dyslipidemia may contribute to pathogenesis and disease complications in limited cutaneous systemic sclerosis (lcSSc), while data about its associations with endothelial dysfunction and clinical lcSSc-specific parameters as well as its predictive role on disease complications are limited. This study investigated the relationship between lipid parameters, endothelial dysfunction, and disease complications in patients with lcSSc. Methods: 38 patients with lcSSc and 38 matched controls with primary Raynaud's phenomenon were analyzed at baseline regarding lipid parameters, parameters of endothelial dysfunction and clinical lcSSc-specific parameters. During a subsequent 3-year follow-up period, patients with lcSSc were prospectively observed for disease complications. Results: Patients with lcSSc exhibited lower high-density lipoprotein (HDL) levels ( Conclusion: Patients with lcSSc showed a more pro-atherogenic lipid profile. Although statistically significant, these results were of modest magnitude and should be interpreted in the context of the exploratory design. Associations with endothelial dysfunction and clinical disease parameters were minimal or non-significant. Selected lipid parameters may be associated with disease complications in lcSSc, but these findings require confirmation in larger, adequately powered studies due to the small sample size and exploratory analyses.
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