Evidence map›Paper›PMID 41953482›Full record

ArticleChemical science2026

Dock & design: engineering specificity for an alternative pimaradiene outcome with the

Mark Schmidt-Dannert, Yue Zhang, Jin Liang, Qiang Wang, Samuel Tufts, Meirong Jia, Dean J Tantillo, Justin B Siegel, Reuben J Peters

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mark Schmidt-DannertRoy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University Ames Iowa 50011 USA rjpeters@iastate.edu.ORCID https://orcid.org/0009-0007-9113-7289
Yue ZhangDepartment of Chemistry, University of California-Davis Davis California 65616 USA djtantillo@ucdavis.edu jbsiegel@health.ucdavis.edu.
Jin LiangRoy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University Ames Iowa 50011 USA rjpeters@iastate.edu.ORCID https://orcid.org/0000-0002-8862-7021
Qiang WangCollege of Agriculture, Guizhou University Guiyang Guizhou 550025 China.ORCID https://orcid.org/0000-0002-7051-8177
Samuel TuftsRoy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University Ames Iowa 50011 USA rjpeters@iastate.edu.
Meirong JiaRoy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University Ames Iowa 50011 USA rjpeters@iastate.edu.
Dean J TantilloDepartment of Chemistry, University of California-Davis Davis California 65616 USA djtantillo@ucdavis.edu jbsiegel@health.ucdavis.edu.ORCID https://orcid.org/0000-0002-2992-8844
Justin B SiegelDepartment of Chemistry, University of California-Davis Davis California 65616 USA djtantillo@ucdavis.edu jbsiegel@health.ucdavis.edu.
Reuben J PetersRoy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University Ames Iowa 50011 USA rjpeters@iastate.edu.ORCID https://orcid.org/0000-0003-4691-8477

Funding

Understanding and manipulating biosynthetic mechanisms for formation of terpenes relevant to human healthR35GM153469 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Dean Tantillo · 2024 to 2026
$1.1M
Investigating labdane-related diterpenoid biosynthesisR35GM156300 · NIGMS · IOWA STATE UNIVERSITY · PI REUBEN JOHN PETERS · 2025 to 2026
$803k
NIGMS NIH HHS R35 GM153469NIGMS NIH HHS R35 GM156300
6 · The paper itself

Abstract

The complexity of the reactions catalyzed by terpene synthases has hindered enzymatic engineering. In most cases such efforts result in non-specific product outcome, with the targeted compound being produced alongside others, hindering further use. Previous work with the structurally characterized

Identifiers

PMID41953482
PMCPMC13054586

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.