ArticleKidney medicine2026
Effect of Sodium Bicarbonate on Indicators of Volume Retention in Metabolic Acidosis After Kidney Transplantation: A Post-Hoc Analysis.
Article in Kidney medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03102996 (Preservation of Kidney Function in Kidney Transplant Recipients by Alkali Therapy), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preservation of Kidney Function in Kidney Transplant Recipients by Alkali Therapy (Preserve-Transplant Study): a Multi-center Randomized Single-blind Placebo- Controlled Trial
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13 authors.
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Abstract
Rationale & Objective: Metabolic acidosis is a frequent complication after kidney transplantation, commonly treated with sodium bicarbonate. However, concomitant sodium loading raises concerns about potential volume retention. This study aims to assess its impact on clinical and biochemical markers of volume retention, as its effects post-transplant remain insufficiently studied. Study Design: Post-hoc analysis of a randomized, single-blinded, placebo-controlled multicenter trial (Preserve-Transplant Study). Setting & Participants: Total of 240 kidney transplant recipients with metabolic acidosis were randomized 1:1 across 3 University hospitals in Switzerland. Intervention: 1.5-4.5 g/day sodium bicarbonate or placebo for 24 months. Outcomes: Primary outcomes included body weight, N-terminal prohormone of brain natriuretic peptide, plasma renin, plasma aldosterone, aldosterone-to-renin ratio (the latter 4 log-transformed), nocturnal systolic blood pressure dipping, and antihypertensive agent use. Secondary outcomes included the occurrence of hypertension, hospitalization due to uncontrolled hypertension or volume overload, and sodium and potassium balance over time. Analytical Approach: Descriptive statistics and mixed-effects regression models. Results: There was weak evidence for treatment effects in the sodium bicarbonate group compared with the placebo group regarding body weight (between-group difference [BGD]: 1.23 kg, 95% CI: -0.18 to 2.63; Limitations: Post-hoc analysis, mainly Caucasian study population. Conclusions: Our findings did not provide clear evidence for unfavorable effects of sodium bicarbonate on volume retention. Further research is required to clarify risks. Trial Registration: ClinicalTrials.gov (ID: NCT03102996).
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