Moderate-intensity treadmill exercise attenuates osteoporotic bone loss in ovariectomized mice via modulation of gut microbiota and glycerophospholipid metabolism.

Xiaochen Meng, Xiuguo Cheng, Longxiao Sun, Chong Wang, Kunyi Huang, Ye Li, Yongjie Yang, Li Gao

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Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

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8 authors.

Xiaochen Meng *College of Sport and Health, Shandong Sport University, Jinan, Shandong, China.

Xiuguo Cheng *College of Sport and Health, Shandong Sport University, Jinan, Shandong, China.

Longxiao SunCollege of Sport and Health, Shandong Sport University, Jinan, Shandong, China.

Chong WangCollege of Sport and Health, Shandong Sport University, Jinan, Shandong, China.

Kunyi HuangDepartment of Health and Physical Education, The Education University of Hong Kong, Tai Po, Hong Kong SAR, China.

Ye LiCollege of Sport and Health, Shandong Sport University, Jinan, Shandong, China.

Yongjie YangCollege of Sport and Health, Shandong Sport University, Jinan, Shandong, China.

Li GaoCollege of Sport and Health, Shandong Sport University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to determine the key gut microbial taxa and metabolites associated with the effects of moderate-intensity treadmill exercise on bone mass in a murine model of post-ovariectomy osteoporosis, using 16S ribosomal RNA sequencing and metabolomic profiling. Methods: Female C57BL/6 mice (12 weeks old) were randomly allocated to one of three groups: sham-operated (SHAM), ovariectomized (OVX), and ovariectomized with exercise intervention (OVX-EX) ( Results: The OVX-EX mice exhibited significantly improved trabecular bone parameters, including BMD, BV/TV, and Tb.N, along with a marked reduction in the abundance of Conclusion: Moderate-intensity treadmill exercise alleviated osteoporotic bone loss in ovariectomized mice, potentially by suppressing the proliferation of

Indexed as

gut microbiotametabolomicsmoderate-intensity treadmill exerciseosteoporosisovariectomized mice

Identifiers

PMID41953460

DOI10.3389/fphys.2026.1752929

PMCPMC13053223

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.