ArticleFrontiers in microbiology2026
Glyphosate resistance as a potential driver for the dissemination of multidrug-resistant clinical strains.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A Pilot Study to Explore the Application of Silicone Wristband-Based Chemical Exposure Assessment to Kidney Disease Epidemiology in Agricultural Workers.Environmental health perspectives · 2026Article
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The rise of antimicrobial resistance (AMR) constitutes a serious threat to global health. Environmental bacterial communities are a key reservoir of AMR genes (ARGs) that can spread to clinical pathogens. Biocides, which include broad-spectrum herbicides, can co-select for ARGs, posing a potential driver for AMR spread. Glyphosate, the world's most widely used herbicide with known bactericidal properties, targets the shikimate pathway and may thus exert selective pressure favoring resistant bacteria, potentially elevating clinical AMR risk from a One Health perspective. We assessed glyphosate resistance in multidrug-resistant (MDR) species isolated from nosocomial infections. Furthermore, we investigated the relationship between glyphosate-resistant environmental species and clinically relevant MDR pathogens using whole-genome sequencing of environmental and clinical strains. Multidrug-resistant species from hospital-acquired infections exhibited high levels of glyphosate resistance. We established a link between glyphosate-resistant environmental species and typically MDR species common in nosocomial settings. Genomic analysis revealed that glyphosate resistance is partially independent of mutations in the target enzyme (5-enolpyruvylshikimate-3-phosphate synthase), suggesting the contribution of alternative mechanisms, such as efflux pumps. Our findings indicate that glyphosate exposure could favor the prevalence of bacteria associated with nosocomial infections and the rise of MDR clinical strains. This suggests that intensive glyphosate use may accelerate the dissemination of AMR. Consequently, the AMR dimension should be incorporated into the environmental risk assessment of biocidal products that are not used as antimicrobial agents.
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