Evidence map›Paper›PMID 41953227›Full record

ArticleNeurosurgical focus: Video2026

Cellular Therapy for In Utero Repair of Myelomeningocele (the CuRe trial): neurosurgical repair video.

Elizabeth Reynolds, Payam Saadai, Cameron Sadegh, Amelia S McLennan, Erin G Brown, Jamie E Anderson, Priyadarsini Kumar, Aijun Wang, Diana L Farmer, Marike Zwienenberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgical focus: Video, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elizabeth ReynoldsDepartment of Surgery.
Payam SaadaiDepartment of Surgery.
Cameron SadeghDepartment of Neurological Surgery.
Amelia S McLennanDepartment of Obstetrics and Gynecology, and.
Erin G BrownDepartment of Surgery.
Jamie E AndersonDepartment of Surgery.
Priyadarsini KumarCenter for Bioengineering in Medicine, University of California, Davis Health, Sacramento, California.
Aijun WangCenter for Bioengineering in Medicine, University of California, Davis Health, Sacramento, California.
Diana L FarmerDepartment of Surgery.
Marike ZwienenbergDepartment of Neurological Surgery.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Management of Myelomeningocele Study (MOMS) established that prenatal repair of myelomeningocele (MMC) improved the rate of ventriculoperitoneal shunt insertion for the treatment of hydrocephalus, compared to postnatal repair. While there was mild improvement of motor function, most children were unable to ambulate independently. Therefore, the ongoing phase 1/2a clinical trial Cellular Therapy for In Utero Repair of Myelomeningocele (CuRe trial) aims to further improve distal neurological function using placenta-derived mesenchymal stem/stromal cells seeded on an extracellular matrix (PMSC-ECM) to augment open fetal repair of MMC. Here, the authors present a video of the neurosurgical repair using the PMSC-ECM. The video can be found here: https://stream.cadmore.media/r10.3171/2026.1.FOCVID25229.

Indexed as

fetalmyelomeningocelespina bifidastem cells

Identifiers

PMID41953227
PMCPMC13055903

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.