Evidence map›Paper›PMID 41953199›Full record

ArticleFrontiers in pharmacology2026

Exploring the therapeutic potential of

Fatima Anjum Faruquee, Tufael Ahmed, Baudrul Mohammad Shahjalal, Utsab Acharya, Milan Rai, Md Kauser Miah, Mohammad A Rashid, Safaet Alam, Yuan Seng Wu, Raquibul Hasan and 3 more

Abstract read
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In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fatima Anjum FaruqueeDepartment of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh.
Tufael AhmedDepartment of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh.
Baudrul Mohammad ShahjalalDepartment of Biomedical Engineering, University of Mississippi, Oxford, MS, United States.
Utsab AcharyaDepartment of Biomedical Engineering, University of Mississippi, Oxford, MS, United States.
Milan RaiDepartment of Biomedical Engineering, University of Mississippi, Oxford, MS, United States.
Md Kauser MiahDepartment of Computer and Information Science, Gannon University, Erie, PA, United States.
Mohammad A RashidPhytochemical Research Laboratory, Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, Bangladesh.
Safaet AlamChemical Research Division, BCSIR Dhaka Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.
Yuan Seng WuDepartment of Biomedical Sciences, Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, Sunway City, Malaysia.
Raquibul HasanDepartment of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA, United States.
Md Moklesur Rahman SarkerDepartment of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh.
Mohd Fahami Nur AzlinaPharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia (The National University of Malaysia), Bangi, Selangor, Malaysia.
Mohsin KaziDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Tetrastigma bracteolatum: (Wall.) Planch, an indigenous plant of Bangladesh, is traditionally used for pain management. This study aimed to determine its biological activities through an integrated Methods: Crude methanol extract was prepared using the maceration technique and fractionated into different solvent fractions. Antioxidant, thrombolytic, and membrane-stabilizing activities were assessed Results: Among the fractions, the chloroform-soluble fraction (CSF) exhibited the highest phenolic content and membrane stabilizing activity, while the aqueous-soluble fraction (AQSF) demonstrated strong antioxidant properties. The petroleum ether fraction showed significant cytotoxic activity. The crude methanol extract exhibited potent antidiarrheal and hypoglycemic effects in mice, with efficacy comparable to standard drugs. The extract significantly exhibited CNS stimulating activity as well. Additionally, it demonstrated analgesic activity by significantly prolonging pain response times and reducing chemically induced pain behaviors in mice. Discussion: These findings suggest that

Indexed as

analgesicantidiarrhealantihyperglycemicanti-oxidantmembrane stabilizingTetrastigma bracteolatumthrombolytic

Identifiers

PMID41953199
PMCPMC13054478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.