Evidence map›Paper›PMID 41953178›Full record

ArticleFrontiers in pediatrics2026

Segmented filamentous bacteria are associated with disease activity in children with inflammatory bowel disease.

Yuling Feng, Huahai Chen, Yeshi Yin, Zhujun Gu, Kai Lin, Weiwei Cheng, Ling Wang, Jing Wang, Jiale Xie, Xiangtao Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuling Feng *Department of Digestive Endoscopy Center, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Huahai Chen *Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Institute of Biology, Guangxi Academy of Sciences, Nanning, China.
Yeshi YinGuangxi Key Laboratory of Animal Reproduction, Breeding and Disease Control, College of Animal Science and Technology, Guangxi University, Nanning, China.
Zhujun GuDepartment of Digestive Endoscopy Center, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Kai LinDepartment of Digestive Endoscopy Center, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Weiwei ChengDepartment of Digestive Endoscopy Center, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ling WangDepartment of Digestive Endoscopy Center, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jing WangKey Laboratory of Comprehensive Utilization of Advantage Plants Resources in Hunan South, College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou, Hunan, China.
Jiale XieKey Laboratory of Comprehensive Utilization of Advantage Plants Resources in Hunan South, College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou, Hunan, China.
Xiangtao LiuKey Laboratory of Comprehensive Utilization of Advantage Plants Resources in Hunan South, College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou, Hunan, China.
Wenyan HuangDepartment of Nephrology, Rheumatology and Immunology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Haifeng LiuDepartment of Digestive Endoscopy Center, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to determine the positivity rate of segmented filamentous bacteria (SFB) in pediatric patients with inflammatory bowel disease (IBD) and to evaluate its association with disease activity. Methods: In this cross-sectional study, 30 pediatric IBD patients and 30 children with functional gastrointestinal disorders were enrolled. SFB in ileal lavage fluid from the terminal ileum were detected using polymerase chain reaction. IBD patients were stratified according to treatment status and disease activity-Untreated Active (UTA), Treated Remission (TRR), Treated Active (TRA)-as well as by disease type (Crohn's disease or ulcerative colitis). SFB positivity rates were compared across subgroups. Within the IBD cohort, disease activity and inflammatory markers, including fecal calprotectin, C-reactive protein, erythrocyte sedimentation rate, platelets count, were compared between SFB-positive and SFB-negative patients. Results: The SFB positivity rate was significantly higher in pediatric IBD patients than in controls (63.3% vs. 36.7%, Conclusions: SFB positivity occurred more frequently in pediatric IBD than in controls-especially in active disease-and was associated with higher inflammatory activity and disease severity.

Indexed as

childrencolonoscopyinflammatory bowel diseasesegmented filamentous bacteriaterminalileum

Identifiers

PMID41953178
PMCPMC13055543

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.