ArticleFrontiers in pediatrics2026
The potential hematological features of children with spastic cerebral palsy in China: a retrospective multidimensional data analysis based on routine hematological indicators.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cerebral palsy (CP) is a non-progressive brain injury primarily characterized by abnormal posture and movement disorders. Among them, spastic cerebral palsy (SCP) accounts for 70% of cases. Previous small sample hematological data analyses have revealed significant differences in inflammatory marker ratios between SCP patients and healthy controls. This study aims to expand the sample size and perform a multidimensional data analysis using routine hematological indicators to identify hematological features of spastic cerebral palsy, potentially providing new directions for the treatment of SCP. Methods: This retrospective study included 305 children with spastic cerebral palsy and 149 healthy children, aged 3-12 years. Previous routine blood and biochemical test results were collected from the participants. Statistical analysis was performed on clinically common indicators and related composite indicators, and subgroup analyses were conducted based on age group (preschool vs. school-age). Results: Compared to the healthy control group, SCP patients had significantly lower levels of NPAR, alkaline phosphatase (ALP), creatinine (Cr), SII, and MPV/PC ( Conclusion: This study reveals a significant association between alkaline phosphatase, creatinine, AST/ALT, SII, MPV/PC, NLR in routine blood indicators and the risk of SCP, providing important reference for clinicians to monitor the health status of children with cerebral palsy, optimize treatment plans, and implement nutritional interventions.
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