Evidence map›Paper›PMID 41953111›Full record

SynthesisFrontiers in dementia2026

Herpes simplex virus 2 and dementia risk: a systematic review and meta-analysis.

C J Hunt, Brinley N Zabriskie, Ethan J Coulter, Morgan Chase McClellan, Grace Templeton, Reagan Erbstoesser, Scott MacLean, Chris H Miller, Jarod Moss, Caitlyn Carter and 4 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

C J HuntDepartment of Biophysics, Brigham Young University, Provo, UT, United States.
Brinley N ZabriskieDepartment of Data Analytics and Information Systems, Utah State University, Logan, UT, United States.
Ethan J CoulterNeuroscience Center, Brigham Young University, Provo, UT, United States.
Morgan Chase McClellanNeuroscience Center, Brigham Young University, Provo, UT, United States.
Grace TempletonDepartment of Psychology, Brigham Young University, Provo, UT, United States.
Reagan ErbstoesserDepartment of Biology, Brigham Young University, Provo, UT, United States.
Scott MacLeanDepartment of Psychology, Brigham Young University, Provo, UT, United States.
Chris H MillerDepartment of Psychology, California State University, Fresno, Fresno, CA, United States.
Jarod MossNeuroscience Center, Brigham Young University, Provo, UT, United States.
Caitlyn CarterDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Shawn D GaleNeuroscience Center, Brigham Young University, Provo, UT, United States.
Jonathan D MooreDepartment of Public Health, University of North Florida, Jacksonville, FL, United States.
Thomas J FarrerSchool of Health and Medical Professions, University of Idaho, Moscow, ID, United States.
Dawson W HedgesNeuroscience Center, Brigham Young University, Provo, UT, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Several potentially modifiable risk factors for dementia have been identified, including infectious diseases. Among the infectious diseases potentially associated with dementia is herpes simplex virus type-2 (HSV-2). Methods: To better characterize the association between HSV-2 and dementia, we conducted a meta-analysis of published peer-reviewed studies reporting HSV-2 exposure and dementia outcomes. Results: Of 626 identified primary studies, eight met our inclusion criteria, with one of these excluded due to overlapping data with another study, yielding seven independent studies (total Discussion: Overall, the available evidence indicates no clear association between HSV-2 and Alzheimer's disease and only one of the two meta-analytic methods shows evidence of a potential relationship with all-cause dementia. These findings support continued investigation into the association between HSV-2 and dementia.

Indexed as

Alzheimer's diseasedementiaherpes simplex virus type 2HSV-2meta-analysis

Identifiers

PMID41953111
PMCPMC13053239

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.