Evidence map›Paper›PMID 41953110›Full record

ArticleOne health (Amsterdam, Netherlands)2026

Metagenomic analysis of antimicrobial resistance genes in domestic canines.

Hillary A Craddock, Yair Motro, Katherine M Winner, Yuval Lotem-Michaeli, Eran Segal, Anastasia Godneva, Dan Grinstein, Jacob Moran-Gilad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in One health (Amsterdam, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hillary A CraddockDepartment of Health Policy and Management, School of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, 1 Ben Gurion Blvd, Building 39, Beer Sheva 8410501, Israel.
Yair MotroDepartment of Health Policy and Management, School of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, 1 Ben Gurion Blvd, Building 39, Beer Sheva 8410501, Israel.
Katherine M WinnerDepartment of Microbiology and Immunology, University of Michigan Medical School, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, USA.
Yuval Lotem-MichaeliDepartment of Health Policy and Management, School of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, 1 Ben Gurion Blvd, Building 39, Beer Sheva 8410501, Israel.
Eran SegalDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, 234 Herzl Street, POB 26, Rehovot 7610001, Israel.
Anastasia GodnevaDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, 234 Herzl Street, POB 26, Rehovot 7610001, Israel.
Dan GrinsteinDepartment of Health Policy and Management, School of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, 1 Ben Gurion Blvd, Building 39, Beer Sheva 8410501, Israel.
Jacob Moran-GiladDepartment of Health Policy and Management, School of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, 1 Ben Gurion Blvd, Building 39, Beer Sheva 8410501, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A One Health approach is critical to addressing the spread of antimicrobial resistance (AMR). A key source of AMR in humans is companion animals, particularly canines. Recent investigation has shown that the canine fecal microbiome is rich in antimicrobial resistant genes (ARGs), yet few studies have studied the resistome of working canines. Our objective was to investigate the resistome of canines to elucidate associations between various exposures and demographic factors and ARG carriage. We performed resistome and microbiome analyses on previously-generated metagenomic sequence data from 126 Israeli working canines and 147 global canines. We found that the canine microbiome and resistome varied significantly with country of origin, and the resistome varied significantly with gastrointestinal disease state, canine job type, and microbiome composition. Tetracycline resistant genes were the most dominant across all canines. Extended-spectrum beta lactamase (ESBL) genes were observed in up to 33% of canines. Genes of concern, including potential carbapenemases (

Indexed as

Antibiotic resistanceEnvironmental healthGenomicsOne healthWorking dogsZoonoses

Identifiers

PMID41953110
PMCPMC13053998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.