ArticleFrontiers in immunology2026
Hypobaric hypoxia can lead to an increase in lung dendritic cells and promote T-cell immunosuppression, thereby preventing the excessive progression of high-altitude pulmonary edema.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- cGAS-STING pathway regulated by spatiotemporal heterogeneity of tumor microenvironment and precision therapy strategies in lung cancer.Journal of experimental & clinical cancer research : CR · 2026Review
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11 authors.
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Abstract
Background: More and more studies have shown that the immune system regulates the body's response to hypoxic stress. Immune dysregulation may increase vascular permeability, leading to edema and tissue damage, thereby causing high-altitude pulmonary edema (HAPE). Here, we found an increase in lung dendritic cells (DCs) in rat and mouse models of HAPE, but its specific role in HAPE remains unclear. Methods: In this study, the function of rat lung DCs and its impact on T cells were analyzed through single-cell sequencing, flow cytometry and Results: We demonstrated that hypobaric hypoxia (HH) induced the recruitment of pulmonary DCs in rats and promoted the immunosuppression of T cells (especially CD4 Conclusions: Our results indicate that hypoxia induces the recruitment of DCs in the lung and mediates the differentiation of T cells into immunosuppressive phenotypes in HAPE rat and mouse models, thereby delaying the progression of HAPE. These findings highlight the potential approach of using immune regulation as a treatment for HAPE.
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