Evidence map›Paper›PMID 41953006›Full record

ArticleFrontiers in immunology2026

Interrogation of glioma immune microenvironment identifies a non-canonical role for microglial Galectin-9 in tumor cell adhesion and phagocytosis.

Pravesh Gupta, Silvana Valdebenito-Silva, Gayatri Kumar, Prashanth Chakrapani, Shivangi Oberai, Minghao Dang, Hiroshi Katayama, Linghua Wang, Eliseo A Eugenin, Krishna P Bhat

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pravesh GuptaDepartment of Cancer Biology, Mayo Clinic, Phoenix, AZ, United States.
Silvana Valdebenito-SilvaDepartment of Neurobiology, John Sealy School of Medicine, The University of Texas Medical Branch (UTMB), Galveston, TX, United States.
Gayatri KumarDepartment of Cancer Biology, Mayo Clinic, Phoenix, AZ, United States.
Prashanth ChakrapaniDepartments of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Shivangi OberaiNeurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Minghao DangGenomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Hiroshi KatayamaDepartments of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Linghua WangGenomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Eliseo A EugeninDepartment of Neurobiology, John Sealy School of Medicine, The University of Texas Medical Branch (UTMB), Galveston, TX, United States.
Krishna P BhatDepartment of Cancer Biology, Mayo Clinic, Phoenix, AZ, United States.

Funding

Tunneling nanotubes are a novel mechanism for the propagation of HIV infection and neurodegenerationK01NS137812 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Silvana A Valdebenito-Silva · 2024 to 2026
$592k
NINDS NIH HHS K01 NS137812
6 · The paper itself

Abstract

Glioma-associated microglia/macrophages (GAMs) have traditionally been described as immunosuppressive. However, within their highly heterogeneous repertoire, pro-phagocytic and cytotoxic subsets with anti-tumoral properties exist. Although macrophages (MACs) can exhibit tumor-suppressive functions, their anti-glioma properties largely remain elusive. To identify anti-glioma myeloid cell effectors, we performed directionally concatenated ligand-receptor (L-R) interactome analyses from dendritic cells (DCs) and microglia (MG) to lymphoid (CD4

Indexed as

Brain NeoplasmsGalectinsGliomaMicrogliaPhagocytosisTumor MicroenvironmentCell AdhesionCell Line, TumorDendritic CellsHumansGalectinsLGALS9 protein, humancell adhesionGalectin-9gliomaligand-receptor interactomemicrogliaphagocytosissingle cell RNA sequencing

Identifiers

PMID41953006
PMCPMC13053254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.