Evidence map›Paper›PMID 41952978›Full record

ArticleiScience2026

Oxytocin ameliorates early life stress-induced anxiety-like behavior by normalizing corticotropin-releasing hormone neuron activity in the PVN.

Cuihui Li, Yunlong Xu, Bingchun Lin, Xiaoyan Huang, Zhixi Huang, Fuxiang Zheng, Lin Zhu, Yingjie Zhu, Chuanzhong Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cuihui LiDepartment of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Shenzhen School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong Province, China.
Yunlong XuDepartment of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Shenzhen School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong Province, China.
Bingchun LinDepartment of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Shenzhen School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong Province, China.
Xiaoyan HuangDepartment of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Shenzhen School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong Province, China.
Zhixi HuangDepartment of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Shenzhen School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong Province, China.
Fuxiang ZhengThe fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 510833, Guangdong, China.
Lin ZhuDepartment of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Shenzhen School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong Province, China.
Yingjie ZhuShenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Chuanzhong YangDepartment of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Shenzhen School of Clinical Medicine, Southern Medical University, Shenzhen, Guangdong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal separation (MS), a prevalent form of early life stress (ELS) exposure, elevates vulnerability to anxiety disorders in later developmental stages. Despite its clinical relevance, the neural mechanisms remain poorly defined. In this study, we demonstrate that ELS-exposed offspring exhibit sustained anxiety-like behaviors. Through integrated c-Fos immunostaining and whole-cell patch-clamp recordings, we identified hyperactivation of corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus (PVN

Indexed as

behavioral neurosciencebiological sciences

Identifiers

PMID41952978
PMCPMC13053683

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.