ArticleSurgery open science2026
Mast cell activation within the mesentery depends on vagal signaling following abdominal surgery.
Article in Surgery open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Abdominal surgery causes an inflammatory reaction in the intestines, resulting in a postoperative ileus. Mast cells can be divided into mucosal mast cells and connective tissue mast cells. In this study, we investigated mast cell activation within the gastrointestinal tract during abdominal surgery and explored the activation and role of connective tissue mast cells in postoperative ileus. Material and Methods: Postoperative ileus was induced in wild-type, Mcpt5-Cre xDTR Results: Surgery induced mast cell degranulation within mesentery. Mast cell degranulation was independent of macrophage activity or mechanical stress, whereas vagotomy prevented mast cell activation in vivo. In vitro, mast cell degranulation was triggered by muscarinic acetylcholine receptors, but not by nicotinic receptors. However, Mcpt5-Cre DTR Conclusions: In conclusion, mast cell activation in the mesentery is induced via muscarinic acetylcholine receptors after surgery. However, depletion of these mast cells did not alter postoperative ileus in mice, suggesting that mast cells do not play a direct role in the pathogenesis of postoperative ileus.
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