Evidence map›Paper›PMID 41952964›Full record

ArticleFrontiers in microbiomes2026

Gut microbiota and its association with gastrointestinal symptoms and pharmacological treatments in a sibling-matched cohort with autism spectrum disorder.

Florencia Peñalba, Andreina Guisande, Lucía Lamberti, Camila Rusiñol, Maite Irastorza, Florencia Konik, Claudio Iglesias, Paula Mendive, Gabriela Garrido, Andrés Parada and 1 more

Abstract read
In one paragraph

Article in Frontiers in microbiomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Florencia PeñalbaMicrobial Genomics Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Andreina GuisandeDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Pereira Rossell Hospital Center, Montevideo, Uruguay.
Lucía LambertiAcademic Unit of Pediatric Psychiatry, School of Medicine, University of the Republic, Montevideo, Uruguay.
Camila RusiñolAcademic Unit of Pediatric Psychiatry, School of Medicine, University of the Republic, Montevideo, Uruguay.
Maite IrastorzaMicrobial Genomics Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Florencia KonikUnidad Académica (U.A.) Área de Investigación, Escuela de Nutrición, Universidad de la República, Montevideo, Uruguay.
Claudio IglesiasDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Pereira Rossell Hospital Center, Montevideo, Uruguay.
Paula MendiveUnidad Académica (U.A.) Área de Investigación, Escuela de Nutrición, Universidad de la República, Montevideo, Uruguay.
Gabriela GarridoAcademic Unit of Pediatric Psychiatry, School of Medicine, University of the Republic, Montevideo, Uruguay.
Andrés ParadaMicrobial Genomics Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Nadia RieraMicrobial Genomics Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder marked by difficulties in communication, social interaction, and restricted, repetitive behaviors. The gut microbiota has emerged as a key factor in the gut-brain axis relevant to ASD. We conducted a cross-sectional study comparing the gut bacterial composition of children with ASD (n=29) and their neurotypical siblings (NT, n=29). To minimize environmental and lifestyle confounders, all pairs were 4 to 10 years old and cohabiting in the same household in Uruguay. We used full-length 16S rRNA gene (V1-V9) sequencing with the latest R10.4.1 Oxford Nanopore Technologies chemistry, enabling high-resolution microbial characterization. While overall β-diversity did not differ significantly between the ASD and NT groups, we identified specific taxonomic shifts. The ASD group was enriched in taxa like

Indexed as

16S rRNAautism spectrum disorder (ASD)gastrointestinal symptoms (GI)microbiomeoxford nanopore amplicon sequencing

Identifiers

PMID41952964
PMCPMC13055624

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.