ArticleFrontiers in medicine2026
Impact of central obesity on esophageal motility and mucosal barrier function based on conventional CT evaluation.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The study aims to automatically quantify visceral and subcutaneous adipose tissue content using computed tomography (CT) for assessing central obesity severity, and to investigate the impact of central obesity on esophageal motility and mucosal barrier function. Methods: This retrospective study included patients who underwent fiberoptic gastroduodenoscopy, high-resolution manometry (HRM), 24-h pH-impedance monitoring, and non-contrast abdominal CT. Participants were stratified into quartiles (Q1-Q4) based on their visceral-to-subcutaneous fat area ratio (V/S), calculated using the TotalSegmentator tool. We compared baseline characteristics, HRM parameters and 24-h pH-impedance parameters across groups. Regression and correlation analyses were performed to evaluate associations between V/S and esophageal motility/mucosal barrier function. Results: Of 185 patients stratified by V/S, Group Q1 (V/S ≤ 1.01, Conclusion: Central obesity significantly disrupts esophageal motility and weakens the esophageal mucosal barrier, thereby precipitating mucosal injury. Varying degrees of central obesity can further impair the integrity of esophageal mucosa by inducing esophageal motility disorders or acid reflux.
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