ArticleInternational journal of reproductive biomedicine2026
Ivermectin mitigates 7,12-dimethylbenz(a) anthracene-induced reproductive toxicity in female wistar rats: An experimental study.
Article in International journal of reproductive biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: 7,12-dimethylbenz(a)anthracene (DMBA) is a pervasive environmental polycyclic aromatic hydrocarbon that exerts genotoxic and endocrine-disrupting effects in female reproductive tissues, largely through oxidative stress and induction of apoptosis. Ivermectin, a food and drug administration-approved antiparasitic agent, has emerging anti-inflammatory and antioxidant properties. Objective: We evaluated whether Ivermectin could protect the ovarian and uterine tissues against DMBA-induced injury. Materials and Methods: In this experimental study, 20 female Wistar rats (8 wk, 210 Results: Our findings showed that DMBA induced significant oxidative stress and tissue damage, along with hormone disruption and upregulation of pro-apoptotic genes. In contrast, Ivermectin co-treatment largely reversed these changes, such as reducing the serum malondialdehyde and increasing superoxide dismutase and total antioxidant capacity. Moreover, the hormone level balance significantly shifted toward control values. Histopathological examination showed DMBA-induced ovarian damage and uterine epithelial degeneration, which were attenuated by Ivermectin. Conclusion: Ivermectin significantly ameliorated DMBA-induced oxidative damage, endocrine disruption, and apoptotic signaling in female rats. These findings suggest Ivermectin's potential for protecting the reproductive tissues from environmental toxin injury.
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