ArticleInternational journal of reproductive biomedicine2026
Comparative effects of adipose-derived mesenchymal stem cells and their exosomes on interleukin-1 beta-induced testicular inflammation in rats: An experimental study.
Article in International journal of reproductive biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Elevated interleukin-1 beta (IL-1β) in orchitis triggers immune-mediated inflammation, disrupting spermatogenesis and impairing reproductive function. Objective: This study compared adipose-derived stem cells (ASCs) and their exosomes (EXO) for mitigating inflammation and enhancing repair in IL-1β-induced orchitis. Materials and Methods: In this experimental study, ASCs were isolated and cultured to passage 3. Flow cytometry and immunocytochemistry confirmed ASCs' surface markers; scanning electron microscopy characterized EXO. 32 male Wistar rats (6-7 wk; 250-300 gr) received daily intraperitoneal IL-1β (10 μg/kg) for 6 days to induce testicular inflammation. Rats were assigned to 4 groups: 1) control; 2) IL-1β only; 3) IL-1β + ASCs (1 Results: ASCs displayed spindle morphology and positivity for CD44 and CD105. Isolated EXO averaged 82.6 Conclusion: Both ASCs and exosome therapies reduced IL-1β-induced inflammation in the rat testis and epididymis. EXO demonstrated superior efficacy, highlighting their significant potential for treating inflammation-induced testicular injury.
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