ArticleFrontiers in neurology
Differential brain iron deposition in Parkinson's disease subtypes: a comparative quantitative susceptibility mapping study of tremor-dominant versus postural instability/gait difficulty phenotypes.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: This study used quantitative susceptibility mapping (QSM) to investigate brain iron deposition patterns in different motor subtypes of Parkinson's disease (PD). We compared tremor-dominant (TD) and postural instability/gait difficulty (PIGD) patients, analyzed the association between iron deposition and core motor symptoms, and further explored its potential as an imaging feature associated with clinical subtypes. Methods: The study included 45 PD patients (25 TD-PD, 20 PIGD-PD) and 23 healthy controls. QSM values were measured in the bilateral caudate nucleus (CN), dentate nucleus (DN), globus pallidus (GP), putamen (PUT), red nucleus (RN), substantia nigra (SN), and thalamus (TH). Results: Compared to controls, both PD groups showed elevated iron levels in multiple brain regions. Notably, TD patients exhibited significantly higher magnetic susceptibility in the DN than both PIGD patients and controls, and DN susceptibility also showed a positive correlation with tremor severity in the overall PD cohort (rs = 0.339, Discussion: These findings suggest that the motor subtypes of Parkinson's disease exhibit distinct brain iron distribution patterns, with the TD subtype showing increased DN iron deposition. This supports the role of the cerebello-thalamo-cortical (CTC) circuit in tremor and highlights dentate nucleus iron deposition as a potential imaging feature associated with the tremor-dominant phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.