ArticleSurgical neurology international2026
Spinal neurosarcoidosis mimicking intramedullary tumors without systemic symptoms: Report of two cases and a systematic review.
Article in Surgical neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Intramedullary spinal neurosarcoidosis is a rare manifestation of sarcoidosis that can mimic intramedullary spinal cord tumors, especially in the absence of systemic symptoms. Its diagnosis is challenging, and management requires a multidisciplinary approach. Case Description: We report two previously healthy male patients presenting with progressive myelopathy due to tumor-like intramedullary lesions. In both cases, limited decompression and diagnostic biopsy revealed noncaseating granulomas consistent with neurosarcoidosis. Postoperative corticosteroid therapy resulted in significant and sustained neurological recovery. One patient required reoperation for mechanical recompression at the cervicothoracic junction. At the latest follow-up, both patients remained relapse-free. A systematic review of surgically treated, histopathology-confirmed intramedullary spinal sarcoidosis cases ( Conclusion: Intramedullary neurosarcoidosis may closely resemble spinal cord tumors in imaging and clinical presentation. Early suspicion, integration of magnetic resonance imaging and cerebrospinal fluid findings, and a conservative surgical approach followed by immunosuppressive therapy can improve outcomes and avoid unnecessary aggressive resections.
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