ArticleFrontiers in oncology2026
Efficacy of local convection enhanced delivery of chemotherapy using an intracerebral osmotic pump in a rat model of glioblastoma.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
16 authors.
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Abstract
Background: Modern protocols for the treatment of glioblastoma multiforme (GBM) involve resection surgery, followed by chemotherapy and radiation therapy and subsequently adjuvant chemotherapy. While modestly successful in prolonging overall survival, peripherally administered chemotherapy drugs have limited ability to cross the blood brain barrier (BBB), limiting their bioavailability, and thus efficacy, at the tumor site. One way of circumventing the BBB is direct delivery of chemotherapy to the tumor site. Direct application of chemotherapy into the resection cavity during surgery in the form of carmustine/bis-chloroethylnitrosourea (BCNU) wafers has had limited success, in part due to the need for wafer solubilization, which restricts drug distribution and efficacy. The primary limitation, however, is that the drug is only distributed over short distances, for a short time. Methods: In this study, we evaluated the efficacy of drug perfusion into the tumor resection cavity in a rat glioma model through convection enhanced delivery (CED), using an implanted microfluidic osmotic pump. We compared the effects of two alkylating agents, BCNU and temozolomide (TMZ), on tumor recurrence and survival. Results: Using pumps containing a high concentration of ferumoxytol - a superparamagnetic iron oxide nanoparticle (SPION) - tissue perfusion was demonstrated Conclusion: BCNU may be an effective choice for CED-driven, locally delivered chemotherapy in GBM.
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