ArticleFrontiers in oncology2026
A rare case of unicentric Castleman disease in the posterior mediastinum: case report and integrated literature review.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Castleman disease (CD) is a complex lymphoproliferative disorder characterized by nonspecific clinical manifestations and imaging features. When occurring within the mediastinum, it is easily confused with other diseases, posing diagnostic challenges. We report a case of unicentric hyaline vascular Castleman disease (UCD) located in the posterior mediastinum. This case report is supplemented by a retrospective analysis of the literature, aiming to enhance understanding and improve diagnostic accuracy for this condition. Case summary: This paper provides a detailed account of the clinical data, imaging findings, diagnostic and therapeutic process of a 28-year-old female patient with a posterior mediastinal UCD. Seven years ago, the patient incidentally found a left posterior mediastinal mass during an outpatient visit for a respiratory tract infection at another hospital. A needle biopsy at that time suggested post-infectious reactive lymphadenopathy. After antimicrobial therapy, respiratory symptoms improved, but intermittent back pain subsequently occurred without prompt attention and follow-up. The patient recently presented for follow-up due to persistent left-sided chest pain unresponsive to analgesics. Imaging examination revealed a significantly enlarged lesion compared to previous findings, now extending to the left thoracic ninth intervertebral foramen region. Additionally, localized increased bone density was observed adjacent to the ninth rib. The patient ultimately underwent complete surgical resection, with postoperative pathology confirming hyaline vascular Castleman disease. No adjuvant radiotherapy or chemotherapy was administered postoperatively. Conclusion: The definitive diagnosis of posterior mediastinal hyaline vascular type CD relies on histopathological examination of surgically resected specimens combined with immunohistochemical staining to establish diagnosis and classification. Imaging features of a hyper-vascular mass in the posterior mediastinum, exhibiting persistent marked enhancement with peri- and intra-tumoral tortuous feeding vessels, may provide valuable diagnostic clues for this disease. Radiologists and relevant clinicians should enhance the recognition of this entity to facilitate the formulation and optimization of diagnostic and therapeutic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.