Evidence map›Paper›PMID 41952403›Full record

ReviewJournal of neurogastroenterology and motility2026

Towards a Standard Protocol for Fecal Microbiota Transplantation in Irritable Bowel Syndrome.

Magdy El-Salhy, Maura Corsetti, Odd Helge Gilja, Sutep Gonlachanvit, Jan Gunnar Hatlebakk, Dag Arne Lihaug Hoff, Perttu Lahtinen, Johan Axel Lunding, Tarek Mazzawi, Tanya M Monaghan and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Magdy El-SalhyDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Maura CorsettiNottingham National Institute for Health Research Nottingham Biomedical Research Centre, and Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, UK.
Odd Helge GiljaNational Centre for Functional Gastrointestinal Disorders and Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Sutep GonlachanvitCentre of Excellence on Neurogastroenterology and Motility, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Jan Gunnar HatlebakkDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Dag Arne Lihaug HoffDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Perttu LahtinenDepartment of Gastroenterology, Päijät- Häme Central Hospital, Lahti, Finland.
Johan Axel LundingDepartment of Medicine, Diakonhjemmet Hospital, Oslo, Norway.
Tarek MazzawiFaculty of Medicine, Al-Balqa Applied University, Salt, Jordan.
Tanya M MonaghanNottingham National Institute for Health Research Nottingham Biomedical Research Centre, and Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, UK.
Bodil OhlssonDepartment of Clinical Sciences, Malmö, Lund University, Lund, Sweden.
Tanisa PatcharatrakulCentre of Excellence on Neurogastroenterology and Motility, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Yong Sung KimDigestive Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Jeonbuk-do, Korea.
Cheol Min ShinDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Randomized controlled trials (RCTs) of fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome (IBS) have produced outcomes varying from no effect at all to high efficacy and durable effects over time. This review analyzed differences in the protocols used in FMT RCTs for IBS in the recently published literature with the aim of identifying the factors responsible for the success or failure of these RCTs. The results of this analysis might be useful in formulating an effective standard protocol for FMT in IBS. A systematic search was conducted in the PubMed database of the literature published in English from January 2015 to December 2023 using several search phrases comprising MeSH expressions. Those RCTs that carefully selected donors based on environmental factors that are known to affect the gut microbiota positively and ensured bacterial diversity before and during FMT produced successful outcomes. Furthermore, direct freezing of the donor's fecal transplant, storing it at -80°C until the FMT is performed, and then thawing it at 4°C and mixing it manually appear to be factors associated with the success of FMT in IBS. Administering the donor's fecal transplant into the small intestine results in durable effects of FMT and long-term colonization of beneficial bacteria. A standard protocol for FMT with large and durable effects should include (1) careful donor selection, (2) handling the donor's fecal transplant in a way that preserves its microbiota contents, and (3) administering the transplant into the small intestine.

Indexed as

DonorFecal microbiota transplantationIrritable bowel syndromeTherapy

Identifiers

PMID41952403
PMCPMC13071414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.