ArticleWorld journal of surgery2026
Is the COBRA-OS 4 French Aortic Occlusion Device Feasible for Partial REBOA?
Article in World journal of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNoncompressible torso hemorrhage is a leading cause of preventable death. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is used to control hemorrhage but full aortic occlusion is limited by distal ischemia. Partial REBOA (pREBOA) allows some distal perfusion to prolong occlusion, but precise balloon titration is difficult with standard devices. The COBRA-OS 4 French (Fr) aortic occlusion catheter was evaluated in vitro and in vivo for partial REBOA.
methodsBench-top (in vitro) and porcine (in vivo) models were used. The titration window of the device was evaluated in a non-hemorrhage porcine model and in a pulsatile aortic model. The ability of the device to maintain a targeted distal aortic pressure (20 mmHg) for an extended period (3 h) was tested in a porcine model of hemorrhagic shock (40% blood volume), with a corresponding in vitro experiment using a pulsatile aortic model.
resultsThe COBRA-OS demonstrated a 3-4 mL linear titration window with 1-1.5 mL deflation volume to reach a target distal aortic pressure of 20 mm Hg in vitro and in vivo. During 3 h of prolonged partial REBOA, the device maintained a stable distal target with a set-and-forget strategy (21 +/- 2 mmHg in vitro and 22 +/-7 mmHg in vivo).
conclusionsThe COBRA-OS 4 Fr device enabled precise, stable partial aortic occlusion in this preclinical model. This is the first demonstration of a 4 Fr REBOA catheter achieving prolonged, controlled partial occlusion in a large-animal hemorrhagic shock model, supporting the feasibility of this device for pREBOA. LEVEL OF EVIDENCE: Basic Science, Animal study.
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