Evidence map›Paper›PMID 41952214›Full record

ArticlePharmacology research & perspectives2026

Clinical-Pharmacological Drug Information Center of Hannover Medical School: Update From a Tertiary Care University Hospital (2022-2024).

Johannes Heck, Dirk O Stichtenoth, Christoph Schröder, Ruxandra Sabau, Anna-Leena K Heim, Felix Koop, Thorben Pape, Sebastian Schröder, Martin Schulze Westhoff, Benjamin Krichevsky and 3 more

Abstract read
In one paragraph

Article in Pharmacology research & perspectives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Johannes HeckInstitute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-5382-3014
Dirk O StichtenothInstitute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-6526-0917
Christoph SchröderInstitute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-3541-8987
Ruxandra SabauInstitute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany.
Anna-Leena K HeimInstitute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany.ORCID 0009-0007-2786-6698
Felix KoopInstitute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-7378-7877
Thorben PapeDepartment of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-1031-1913
Sebastian SchröderDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-0905-274X
Martin Schulze WesthoffDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-3262-8137
Benjamin KrichevskyInstitute for General Practice and Palliative Care, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-5899-0113
Martin KlietzDepartment of Neurology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-3054-9905
Stephan GretenDepartment of Neurology, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-0638-8571
Carsten SchumacherInstitute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-3012-4245

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug information centers (DICs) are institutions dedicated to providing independent and up-to-date information on medications and their usage to healthcare professionals. Here, we provide an update from the clinical-pharmacological DIC of Hannover Medical School, covering the period from April 2022 to December 2024. In total, 438 queries were evaluated. Potential differences between patient-specific and general queries were analyzed with Pearson's chi-squared test or Fisher's exact test. The Holm-Bonferroni method was applied to counteract the problem of multiple comparisons. A curated selection of ten clinically interesting and educational queries is presented and discussed. 85.2% of the queries were patient-specific, and 95.7% were submitted by physicians, predominantly internists, psychiatrists, and surgeons. Indications/contraindications, adverse drug reactions, and pharmacodynamic interactions (PDIs) represented the three most frequent query categories. Compared to our previous research, we observed increases in queries about pharmacotherapy in advanced age and drug use during pregnancy or breastfeeding. As compared to general queries, patient-specific queries were significantly more often related to indications/contraindications (26.2% vs. 49.6%; p < 0.001) and PDIs (24.6% vs. 44.5%, p = 0.003) after adjusting for multiple comparisons. The query characteristics remained relatively stable between our previous investigation and the current analysis (2022-2024), in particular with respect to type of queries, profession of inquiring healthcare professionals, medical specialties of inquirers, and query categories. Changes mainly pertained to higher proportions of queries about pharmacotherapy in advanced age and drug use during pregnancy or breastfeeding.

Indexed as

Drug Information ServicesDrug-Related Side Effects and Adverse ReactionsFemaleGermanyHospitals, UniversityHumansSchools, MedicalTertiary Care Centersclinical pharmacologydrug information centerpharmacotherapy safety

Identifiers

PMID41952214
PMCPMC13061747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.