ArticleBMC oral health2026
Effect of calcium hydroxide vs. tobradex intracanal medicament on postoperative endodontic pain: a pragmatic prospective study.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07332936 (Effect of Calcium Hydroxide vs. Tobradex Intracanal Medicament on Postoperative Endodontic Pain), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Calcium Hydroxide vs. Tobradex Intracanal Medicament on Postoperative Endodontic Pain: A Prospective Trial
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4 authors.
Funding
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Abstract
This pragmatic study provides preliminary evidence on the effectiveness of calcium hydroxide (Ca(OH)₂) and Tobradex (a tobramycin–dexamethasone combination) as intracanal medicaments for managing postoperative pain following emergency root canal treatment in patients with symptomatic irreversible pulpitis. Forty-three adults participated (27 received Ca(OH)₂ and 16 received Tobradex). Pain intensity was evaluated using a numeric rating scale before treatment and at 24 and 48 h postoperatively. Both groups showed significant pain reduction at 24 h, but Tobradex produced a greater and faster decrease (mean pain reduction from 7.69 ± 3.68 to 1.31 ± 2.36; P < 0.001) compared to calcium hydroxide (median reduction from 7.0 to 2.0; P = 0.006). No further improvement occurred between 24 and 48 h for either group, and demographic factors had no significant influence. Overall, Tobradex demonstrated superior short-term analgesic efficacy, indicating that corticosteroid–antibiotic combinations may enhance postoperative comfort more effectively than calcium hydroxide in endodontic emergency cases.Trial registrationThe study protocol was retrospectively registered in Clinicaltrials.gov on 13th of Jan. 2026, with ID number NCT07332936.
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