Evidence map›Paper›PMID 41952142›Full record

ArticleBMC medicine2026

Causal modeling of school aversion in psychiatrically referred adolescents: a DoWhy-based analysis.

Mengmeng Zhang, Xin Ma, Hui Li, Botao Huang, Yuhan Luo, Jie Qian, Meijuan Wang

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Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Mengmeng Zhang *Department of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Baden-Württemberg, Germany.
Xin Ma *Peking University Institute of Mental Health (Sixth Hospital), Key Laboratory of Mental Health of National Health Commission, National Clinical Research Center for Mental Diseases, Peking University, Beijing, China.
Hui LiShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Botao HuangShanghai University, Shanghai, China.
Yuhan LuoShanghai University, Shanghai, China.
Jie QianShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. bsb.qianjie@126.com.
Meijuan WangDepartment of Psychiatry, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai, China. wmjyhn@163.com.

Funding

Shanghai Data Sharing and Emulation of Clinical Trials, CCS-DASET SHDC2024CRI008Shanghai Data Sharing and Emulation of Clinical Trials, CCS-DASET SHDC2024CRI009Yangpu District Health System Research Project in Public Health,Shanghai YPGWM202502
6 · The paper itself

Abstract

backgroundSchool aversion is increasingly recognized in adolescents and has been linked to emotional distress, suicide risk, and academic failure. However, studies rely on correlational analysis, making it unclear which risk factors truly cause school aversion. To address this gap, we combined directed acyclic graph (DAG)-based modeling, DoWhy-based causal effect estimation, and counterfactual simulation to explore psychosocial pathways related to school aversion in clinically referred adolescents.

methodsParticipants were clinically referred adolescents from mental health services who completed standardized psychosocial assessments. Variables were obtained through validated instruments and clinical intake records, covering demographics, adversity, personality, and symptoms. Causal inference was conducted through a combined framework of DAG learning, DoWhy estimation with backdoor propensity-score weighting and logistic-model-based counterfactual simulation. All analyses were performed using Python 3.11.8, with pgmpy, DoWhy, and scikit-learn as core libraries.

resultsA total of 423 adolescents were assessed, with 57.7% showing school aversion or refusal and 39.7% reporting suicidal thoughts or attempts. DAG modeling identified several school aversion-adjacent relationships, with family structure, bullying, and digital addiction retained as primary school-aversion-centered pathways in downstream analyses, whereas trauma remained a nearby contextual factor. DoWhy analysis showed that the retained associations were SchoolAversion → Bullying [average treatment effect (ATE) = 0.046, p = 0.001] and SchoolAversion → DigitalAdd (ATE = 0.036, p = 0.008), while family structure showed a significant negative effect on school aversion (ATE = -0.162, p = 0.031). Counterfactual simulation showed that removing bullying or digital addiction had relatively small effects on school aversion. In exploratory counterfactual simulations, SchoolAversion → Suicide showed a risk difference of 0.266 (bootstrap 95% CI 0.182 to 0.346).

conclusionsAmong clinically referred adolescents, school aversion appeared not only as an outcome linked to upstream psychosocial context, but also as a central factor associated with downstream bullying, digital addiction, and suicide risk in the present framework. This integrated causal framework may help refine risk screening and intervention prioritization in clinical populations, while further validation in non-clinical and longitudinal samples is needed.

Indexed as

Adolescent BehaviorSchoolsAdolescentBullyingFemaleHumansMaleRisk FactorsSuicidal IdeationAdolescentsCausal inferenceCounterfactual simulationPsychosocial risk factorsSchool aversion

Identifiers

PMID41952142
PMCPMC13173802

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.