ArticleBMC cardiovascular disorders2026
Discriminating established cardiovascular disease using a novel multiterritory ultrasound plaque burden measure (wTPT): findings from the P-SONAR study.
Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06933745 (Ultrasound of Carotid and Femoral Plaque Burden and Non-alcoholic Fatty Liver Disease as Predictors of Cardiovascular Disease), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ultrasound of Carotid and Femoral Plaque Burden and Non-alcoholic Fatty Liver Disease as Predictors of Cardiovascular Disease
Who cites it
1 citing paper in PubMed.
- Correction: Discriminating established cardiovascular disease using a novel multiterritory ultrasound plaque burden measure (wTPT): findings from the P-SONAR study.BMC cardiovascular disorders · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveUltrasound-imaging of subclinical atherosclerosis may refine cardiovascular (CV) risk assessment, but quantification methods vary and often include carotid arteries only. Because atherosclerosis is multiterritory, global (carotid–femoral) plaque quantification may better reflect systemic burden. We examined whether a novel multiterritory measure, weighted total plaque thickness (wTPT), better discriminates established CV disease than traditional risk factors and plaque measures.
methodsIn 5 418 participants (59.8 ± 8.1 years; 53.0% women) from the Prospective Screening Of Non-invasive Atherosclerosis Risk study, plaque burden was assessed across 12 carotid and femoral segments using wTPT, maximal plaque thickness (MPT), plaque count, and number of arteries with plaque. Discrimination of prior CV disease was evaluated using c-statistics, net reclassification improvement (NRI), and integrated discrimination improvement (IDI).
resultsGlobal wTPT showed the strongest discrimination of established CV disease (c-statistic 0.85 [95% CI: 0.83–0.87]), outperforming alternative plaque measures (p < 0.001). Adding global wTPT to risk factors improved discrimination from 0.84 to 0.89 (95% CI: 0.87–0.91), NRI 0.71 (95% CI: 0.57–0.84) and IDI 0.058 (95% CI: 0.004–0.071). Femoral wTPT outperformed carotid wTPT (p < 0.001), and global wTPT exceeded both (p = 0.014). Across wTPT quartiles, odds of prior CV disease increased stepwise: 2.0 (95% CI: 0.89–4.4), 4.2 (95% CI: 2.0–8.6), and 10.0 (95% CI: 5.0–20.1) versus the lowest quartile.
conclusionGlobal wTPT showed superior discrimination of established CV disease and added substantial incremental discriminative value beyond standard risk factors. These findings support wTPT as a marker of systemic atherosclerosis and a strong candidate for future outcome-based risk refinement. If prospectively validated, wTPT may contribute to improved risk stratification by identifying individuals with a high systemic atherosclerotic burden.
trial registrationClinicaltrials.gov. Identifier: NCT06933745. Registered 22 april 2025.
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