ArticleAllergy2026
Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier-On-Chip and Interfacial Interactions With Human Serum Albumin.
Article in Allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
Abstract
Under the influence of environmental pollution, chronic non-communicable diseases have increased. The epithelial lining of the airway forms the initial barrier; however, upon exposure, nanoplastics (NPs) may cross this interface and enter systemic circulation. This study aims to elucidate the effects of polypropylene nanoplastics (PP NPs) on the epithelial barrier and the interactions with serum proteins. PP beads were chemically degraded, characterized, and administered to the epithelial barrier-on-chip at a dose of 250 μg/mL, followed by continuous perfusion for 3 days. Their colloidal and biological behavior was investigated in cell culture medium supplemented with 10% fetal bovine serum. To explore clinical relevance, the interaction of PP NPs with human serum albumin was analyzed using molecular dynamics simulations, supported by protein profiling of plasma samples from healthy male and female individuals to understand gender-related differences. PP NPs with an average size of 305 nm were exposed to the epithelial barrier-on-chip leading to a decrease in cell viability via apoptotic cell death and transepithelial electrical resistance (TEER) value from ~2600 to 2200 Ω·cm
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