Evidence map›Paper›PMID 41952035›Full record

ArticleAging cell2026

Physical Fitness Is Negatively Associated With DNA Methylation-Based Risk of Aging-Related Diseases.

Samiha Nasser, Johanna Keringer, Yaodong Gu, Istvan Boldogh, Xueqing Ba, Mitsuru Higuchi, Csaba Kerepesi, Zsolt Radak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samiha NasserHUN-REN Institute for Computer Science and Control (SZTAKI), Budapest, Hungary.
Johanna KeringerDoctoral School, and Research Center for Molecular Exercise Science, Hungarian University of Sport Science, Budapest, Hungary.
Yaodong GuFaculty of Sport Science, Ningbo University, Ningbo, China.
Istvan BoldoghDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Xueqing BaDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun, China.
Mitsuru HiguchiFaculty of Sport Sciences, Waseda University, Tokorozawa, Japan.
Csaba KerepesiHUN-REN Institute for Computer Science and Control (SZTAKI), Budapest, Hungary.ORCID 0000-0001-9541-246X
Zsolt RadakDoctoral School, and Research Center for Molecular Exercise Science, Hungarian University of Sport Science, Budapest, Hungary.

Funding

European Commission RRF-2.3.1-21-2022-00004Hungarian research network TKCS-2024/37Nemzeti Kutatási, Fejlesztési és Innovaciós Alap OTKA142192Nemzeti Kutatási Fejlesztési és Innovációs Hivatal 146113University of Edinburgh
6 · The paper itself

Abstract

Physical fitness is a key determinant of health, yet the molecular pathways linking fitness to the risk of aging-related diseases remain unclear. We examined associations between DNA methylation-based protein level estimates (EpiScores) and five fitness traits-VO

Indexed as

AgingDNA MethylationPhysical FitnessAgedBody Mass IndexFemaleHumansMaleMiddle AgedRisk Factors

Identifiers

PMID41952035
PMCPMC13061595

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.