Evidence map›Paper›PMID 41952019›Full record

ArticleBiological trace element research2026

Associations between Dietary Selenium Intake and Risk of Incident Arthritis: Based on UK Biobank WebQ Assessment (2009-2012).

Xuena Yang, Chen Liu, Jin Feng, Shiqiang Cheng, Chuyu Pan, Wenming Wei, Dan He, Boyue Zhao, Jingni Hui, Li Liu and 7 more

Erratum issuedAbstract read
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In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Xuena YangKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Chen LiuKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Jin FengKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Shiqiang ChengKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Chuyu PanKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Wenming WeiKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Dan HeKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Boyue ZhaoKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Jingni HuiKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Li LiuKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Yan WenKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Yumeng JiaKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Huan LiuKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Alexey A TinkovCenter of Bioelementology and Human Ecology, Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya St., 2-4, Moscow, 119146, Russia.
Anatoly V SkalnyCenter of Bioelementology and Human Ecology, Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya St., 2-4, Moscow, 119146, Russia.
Bolun ChengKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Feng ZhangKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China. fzhxjtu@mail.xjtu.edu.cn.

Funding

the National Natural Science Foundation of China 82361138566the Natural Science Basic Research Plan in Shaanxi Province of China 2021JCW-08the Russian Science Foundation 24-45-00073
6 · The paper itself

Abstract

Although previous studies investigated the association between dietary selenium (Se) intake and arthritis risk, with inconsistent results. Our study aims to assess whether Se intake can delay arthritis onset through a large-scale, long-term population-based cohort. 133,230 - 153,247 arthritis-free participants from the UK Biobank were included. Arthritis was defined using ICD-10 codes. Dietary Se intake was evaluated through 24-hour dietary recall questionnaires. Association between Se intake and incident arthritis was evaluated using accelerated failure time model. Additionally, we conducted subgroup analysis stratified by age, sex, body mass index (BMI) and genetic risk. Over a median follow-up period of 8.07 years, 1,175 RA cases and 13,413 OA patients were identified. Dietary Se can delay RA onset, with the following time ratios (TR) (Q2 VS Q1: TR (95% CI) = 1.25 (1.12, 1.40); Q3 VS Q1: TR (95% CI) = 1.26 (1.13, 1.41); Q4 VS Q1: TR (95% CI) = 1.25 (1.12, 1.40); P for trend < 0.001)). Similarly, Se intake can delay OA onset (Q3 VS Q1: TR (95% CI) = 1.06 (1.02, 1.10), P = 0.001)). Subgroup analyses revealed that Se intake delayed RA onset in younger individuals and females, and postponed OA onset in individuals with high BMI and high genetic risk. Our study suggests that Se intake may protect against RA and OA. These findings provide new insights for primary prevention strategies and dietary interventions aimed at reducing arthritis risk.

Indexed as

ArthritisArthritis, RheumatoidDietOsteoarthritisSeleniumAdultAgedBiological Specimen BanksFemaleHumansIncidenceMaleMiddle AgedRisk FactorsSurveys and QuestionnairesUnited KingdomSeleniumDietary seleniumOsteoarthritisProspective cohort studyRheumatoid arthritis

Identifiers

PMID41952019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.