ReviewJournal of community genetics2026
Genetic disorders and congenital anomalies in Nigeria: a scoping review.
Review in Journal of community genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pattern and Outcome of Congenital Anomalies Seen in the Newborn Unit of a Tertiary Hospital in North-East Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nigeria, with its rich cultural and genetic diversity, faces a largely undocumented burden of genetic disorders and congenital anomalies. Understanding this burden is vital for effective healthcare planning and interventions. The aim of this study was to provide a comprehensive overview of the prevalence and geographical distribution of genetic disorders and congenital anomalies in Nigeria based on published evidence. A systematic scoping review was conducted across seven databases using tailored search strategies. Screening was performed in two stages: (1) title and abstract and (2) full text- prior to data extraction and analysis. Prevalence figures were recalculated and standardized as a percentage of live births or individuals. Seventy-eight studies met the inclusion criteria, of which 27 reported at least one genetic disorder. Hemoglobinopathies–particularly sickle cell disease (SCD) and sickle cell traits–were the most frequently reported conditions, with prevalence estimates as high as 61%, underscoring Nigeria’s substantial disease burden. Glucose-6-phosphate dehydrogenase (G6PD) deficiency was also commonly reported, with prevalence reaching up to 60% in some populations. Congenital anomalies involving the central nervous system, musculoskeletal system, cardiovascular system, and genitourinary tract were frequently described, with reported prevalence estimates of up to 13%, 8.8%, 3% and 6.7%, respectively. Geographically, studies were disproportionately concentrated in the southern regions, while northern areas–particularly the Northeast–were markedly underrepresented. Significant regional and condition-specific knowledge gaps persist regarding genetic disorders and congenital anomalies in Nigeria, especially in the North. Strengthening surveillance systems, expanding regionally representative research, and implementing targeted public health interventions are critical to inform equitable healthcare planning and reduce disease burden.
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Registered trials
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