Evidence map›Paper›PMID 41951963›Full record

ArticleRheumatology international2026

Validation of the Dudley inflammatory bowel symptom questionnaire for assessing gastrointestinal symptom burden in axial spondyloarthritis.

Meryem Ozoglu, Duygu Temiz Karadag, Neslihan Gokcen, Ozlem Ozdemir Isik, Hasan Yilmaz, Ayse Cefle, Ayten Yazici

Abstract readValidation Study
In one paragraph

Article in Rheumatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meryem OzogluDepartment of Internal Medicine, School of Medicine, Kocaeli, Turkey.ORCID http://orcid.org/0000-0001-5467-050X
Duygu Temiz KaradagDepartment of Internal Medicine, Division of Rheumatology, Kocaeli University, School of Medicine, Kocaeli, Turkey.ORCID http://orcid.org/0000-0002-5891-2032
Neslihan GokcenDepartment of Internal Medicine, Division of Rheumatology, Kocaeli University, School of Medicine, Kocaeli, Turkey. drngokcen@hotmail.com.ORCID http://orcid.org/0000-0003-3022-493X
Ozlem Ozdemir IsikDepartment of Internal Medicine, Division of Rheumatology, Kocaeli University, School of Medicine, Kocaeli, Turkey.ORCID http://orcid.org/0000-0002-2985-3723
Hasan YilmazDepartment of Internal Medicine, Division of Gastroenterology, Kocaeli University, School of Medicine, Kocaeli, Turkey.ORCID http://orcid.org/0000-0003-1850-8825
Ayse CefleDepartment of Internal Medicine, Division of Rheumatology, Kocaeli University, School of Medicine, Kocaeli, Turkey.ORCID http://orcid.org/0000-0002-3273-7969
Ayten YaziciDepartment of Internal Medicine, Division of Rheumatology, Kocaeli University, School of Medicine, Kocaeli, Turkey.ORCID http://orcid.org/0000-0003-2167-4509

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subclinical and overt inflammatory bowel disease (IBD) is frequently observed in patients with axial spondyloarthritis (ax-SpA), traditionally identified through invasive ileocolonoscopic evaluation. Validated non-invasive assessing instruments are therefore needed to facilitate early detection. This study aimed to validate the Turkish version of the Dudley Inflammatory Bowel Symptom Questionnaire (DISQ) as a tool for assessing gastrointestinal symptom burden suggestive of intestinal involvement in patients with axial spondyloarthritis. In this cross-sectional validation study, 174 patients fulfilling the 2009 Assessment of SpondyloArthritis international Society (ASAS) criteria for axial SpA were enrolled. Convergent validity was assessed by examining correlations between DISQ scores and disease activity (Bath Ankylosing Spondylitis Disease Activity Index [BASDAI]), functional status (Bath Ankylosing Spondylitis Functional Index [BASFI]), and health-related quality of life (Short Form-36 [SF-36]). Discriminant validity was evaluated by comparing DISQ scores in patients with and without gastrointestinal symptoms suggestive of IBD. Test–retest reliability was assessed by re-administration of the DISQ after one month. Internal consistency was evaluated using Cronbach’s alpha. DISQ scores demonstrated moderate positive correlations with BASDAI (r = 0.432, p < 0.001) and BASFI (r = 0.248, p = 0.001), and a strong inverse correlation with SF-36 scores (p < 0.001), supporting convergent validity. Patients reporting diarrhea, abdominal pain, oral aphthae, or mucus in stool had significantly higher DISQ scores than those without these symptoms (all p ≤ 0.008), confirming discriminant validity. The Turkish version of the DISQ demonstrated acceptable internal consistency (Cronbach’s α = 0.70) and good test–retest reliability (ICC = 0.76; 95% CI: 0.51–0.82; p < 0.001). The Turkish version of DISQ demonstrates satisfactory validity and reliability as a non-invasive assessment instrument for gastrointestinal symptoms suggestive of bowel inflammation in patients with ax-SpA. Future studies incorporating endoscopic and biomarker-based outcomes are warranted to define clinically meaningful cut-off values and determine its role in routine clinical practice.

Indexed as

Axial SpondyloarthritisInflammatory Bowel DiseasesAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsQuality of LifeReproducibility of ResultsSeverity of Illness IndexSurveys and QuestionnairesSymptom BurdenTurkeyYoung AdultAxial spondyloarthritisDudley inflammatory bowel symptom questionnaireInflammatory bowel diseaseQuestionnaire

Identifiers

PMID41951963
PMCPMC13061768

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.