Evidence map›Paper›PMID 41951910›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2026

NMN Can Restore Ovarian Reserve in Aged Mice by Upregulating NAD

Jing Wang, Qiqi Zhang, Bo Yan, Yongqi Fan, Dandan Yang, Ding Ding, Chao Zhang, Rufeng Xue, Beili Chen, Huijuan Zou and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jing Wang *Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China.
Qiqi Zhang *Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China.
Bo Yan *The Second Clinical Medical School, Anhui Medical University, Hefei City, Anhui, China.
Yongqi FanReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China.
Dandan YangReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China.
Ding DingReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China.
Chao ZhangReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China.
Rufeng XueReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China.
Beili ChenReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China.
Huijuan ZouReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China.
Weiwei ZouReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China.
Tinting YeReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China.
Qiushuang WangReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China. 664715084@qq.com.
Huiru ChengReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China. chenghuiru008@163.com.
Zhiguo ZhangReproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei City, Anhui, China. zzg_100@163.com.ORCID http://orcid.org/0000-0003-1483-3321
Weihua HuReproductive Medicine Center of the First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China. weihuahu@126.com.

Funding

Hefei Comprehensive National Science Center Medical-Industrial Integration Medical Equipment Innovation Research Platform Project No. HFGJKXZX-YGRH-2-001Key projects of Anhui Provincial Health Commission No. AHWJ2022a002National Key Research and Development Program of China No. 2022YFC2703000The University Natural Foundation of Anhui Educational Committee No. KJ2021A0264
6 · The paper itself

Abstract

Female reproductive aging is linked to declining nicotinamide adenine dinucleotide (NAD+) levels and mitochondrial dysfunction. While nicotinamide mononucleotide (NMN) supplementation can counteract this, its mechanisms remain unclear. This study investigated NMN’s effects in aged female mice administered 200, 500, or 1000 mg/kg/day NMN for 10 days, compared to aged and young controls. An optimal dose of 500 mg/kg/day was identified for restoring ovarian follicle reserve. This treatment significantly increased ovarian NAD+ and ATP, reduced oocyte oxidative stress (ROS) and apoptosis, and rejuvenated mitochondrial function. Mechanistically, NMN activated the NAD+/SIRT1/PGC-1α signaling pathway and upregulated the mitochondrial biogenesis protein TOMM20. In vitro, supplementing culture medium with 1 µM NMN optimally enhanced the developmental potential of aged oocytes. Both in vivo and in vitro interventions showed dose-dependent efficacy. We conclude that NMN mitigates ovarian aging by enhancing mitochondrial function via the NAD+/SIRT1/PGC-1α-TOMM20 axis.

Indexed as

AgingMembrane Transport ProteinsNADNicotinamide MononucleotideOocytesOvarian ReservePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSirtuin 1AnimalsApoptosisCellular SenescenceFemaleMiceMitochondriaMitochondrial Precursor Protein Import Complex ProteinsOxidative StressMembrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsNADNicotinamide MononucleotidePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseSirt1 protein, mouseSirtuin 1In vitro fertilizationMitochondrial functionNicotinamide adenine dinucleotideNicotinamide mononucleotidePGC-1αSIRT1TOMM20

Identifiers

PMID41951910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.